(S)-(-)-2-氨基-4-戊烯酸合成路线 （共 74 条）
反应条件
ammonia; sodium in tetrahydrofuran
参考文献
Arnold, Lee D.; Drover, John C. G.; Vederas, John C.
Journal of the American Chemical Society, 1987 , vol. 109, # 15 p. 4649 - 4659
反应条件
ammonia; sodium in tetrahydrofuran
参考文献
Arnold, Lee D.; Drover, John C. G.; Vederas, John C.
Journal of the American Chemical Society, 1987 , vol. 109, # 15 p. 4649 - 4659
反应条件
lithium hydroxide T=38°C; 12 h; porcine kidney acylase I;
参考文献
Cox, Russell J.; Sherwin, William A.; Lam, Lister K. P.; Vederas, John C.
Journal of the American Chemical Society, 1996 , vol. 118, # 32 p. 7449 - 7460
反应条件
1: With lithium hydroxide; dihydrogen peroxide in tetrahydrofuran; water T=20°C; Hydrolysis; 12 h; 2: With hydrogenchloride in tetrahydrofuran; water T=20°C; Hydrolysis; 24 h; Further stages.;
参考文献
Guillena; Najera
Journal of Organic Chemistry, 2000 , vol. 65, # 22 p. 7310 - 7322
反应条件
D-amino acid oxidase; E. coli branched-chain amino acid aminotransferase in water T=37°C; 72 h; Tris buffer, pH 8.5, 1mM EDTA, monosodium glutamate, bovine serum albumin, catalase, pyridoxal 5'-phosphate;
参考文献
Shah; Schafer; Recchia; Polach; LeMaster
Tetrahedron Letters, 1994 , vol. 35, # 1 p. 29 - 32
反应条件
ammonia; lithium in tetrahydrofuran; ethanol 1 h; Yields of byproduct given;
参考文献
Williams, Robert M.; Sinclair, Peter J.; Zhai, Dongguan; Chen, Daimo
Journal of the American Chemical Society, 1988 , vol. 110, # 5 p. 1547 - 1557
反应条件
boron trifluoride diethyl etherate in acetonitrile 3 h; Ambient temperature;
参考文献
Katagiri, Nobuya; Okada, Makoto; Kaneko, Chikara; Furuya, Toshio
Tetrahedron Letters, 1996 , vol. 37, # 11 p. 1801 - 1804
反应条件
lithium hydroxide in tetrahydrofuran; water T=20°C; Hydrolysis;
参考文献
Guillena; Najera
Journal of Organic Chemistry, 2000 , vol. 65, # 22 p. 7310 - 7322
反应条件
1: glycine With pyridine-2-carboxylic acid(2-benzoyl-phenyl)-amide; sodium methylate; nickel(II) nitrate hexahydrate in methanol 0.333333 h; Heating; 2: allyl bromide With sodium hydroxide; (R)-NOBIN in dichloromethane T=20°C; 0.5 h; 3: With hydrogenchloride in methanol; water Heating;
参考文献
Angewandte Chemie - International Edition, , vol. 40, # 10 p. 1948 - 1951
反应条件
1: glycine With pyridine-2-carboxylic acid(2-benzoyl-phenyl)-amide; sodium methylate; nickel(II) nitrate hexahydrate in methanol 0.333333 h; Heating; 2: 3-iodoprop-1-ene With sodium hydroxide; (R)-NOBIN in dichloromethane T=20°C; 0.0666667 h; 3: With hydrogenchloride in methanol; water Heating;
参考文献
Angewandte Chemie - International Edition, , vol. 40, # 10 p. 1948 - 1951
