4-甲氨基-3-硝基吡啶合成路线 （共 18 条）
反应条件
in dichloromethane; water T=40°C; 1 h;
参考文献
BIOMARIN PHARMACEUTICAL INC.; WANG, Bing; CHU, Daniel
Patent: WO2011/130661 A1, 2011 ;
Location in patent: Page/Page column 173 ;
反应条件
methylamine in ethanol
参考文献
American Home Products Corporation
Patent: US5723468 A1, 1998 ;
US 5723468 A
反应条件
N-methylamine hydrochloride; potassium carbonate in 1,4-dioxane
反应条件
in methanol T=80°C; 60 h;
参考文献
EP1568699 A1, ;
Page/Page column 82 ;
反应条件
in ethanol; water 3 h; Reflux;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; Nickolaus, Peter
Patent: US2013/225609 A1, 2013 ;
Location in patent: Paragraph 0406; 0407 ;
反应条件
sulfuric acid T=20°C; 24 h;
参考文献
Kyziol; Broda; Zaleski; Daszkiewicz
Journal of Molecular Structure, 2002 , vol. 605, # 2-3 p. 157 - 169
参考文献
Justus Liebigs Annalen der Chemie, , vol. 518, p. 274,287
反应条件
sulfuric acid T=160°C; 2 h;
参考文献
Sepiol, J.; Tomasik, P.
Acta Chimica Hungarica, 1983 , vol. 113, # 2 p. 159 - 164
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 14 p. 3402 - 3406
反应条件
1: 55 percent / sulphuric acid; nitric acid; sulphamic acid / 0.5 h / room t. 2: 58 percent / sulphuric acid / 24 h / 20 °C View Scheme
参考文献
Journal of Molecular Structure, , vol. 605, # 2-3 p. 157 - 169
