5-异氰基-4-甲基-苯基-1,3-噻唑合成路线 （共 11 条）
反应条件
4-(N,N-dimethlyamino)pyridine in tetrahydrofuran T=20°C; 1 h;
参考文献
Freed; Hart; Magomedov
Journal of Organic Chemistry, 2001 , vol. 66, # 3 p. 839 - 852
反应条件
1: 93 percent / thionyl chloride / 18 h / 20 °C 2: 98 percent / DMAP / acetonitrile / 1 h / 20 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 122, # 31 p. 7614 - 7615
反应条件
1.1: HCl; NaNO2 / H2O / 0.25 h / 0 °C 1.2: 63 percent / KOH / ethanol; H2O / 15 h / 0 - 4 °C / pH 6.0 2.1: 732 mg / acetic acid / H2O / 15 h / 20 °C 3.1: 85 percent / HBr / acetic acid / 2 h / 20 °C 4.1: DBU / 3 h / Heating 5.1: 99 percent / 4-dimethylaminopyridine / tetrahydrofuran / 1 h / 20 °C View Scheme
参考文献
Bulletin of the Chemical Society of Japan, , vol. 77, # 5 p. 1021 - 1025
反应条件
1: DBU / 3 h / Heating 2: 99 percent / 4-dimethylaminopyridine / tetrahydrofuran / 1 h / 20 °C View Scheme
参考文献
Bulletin of the Chemical Society of Japan, , vol. 77, # 5 p. 1021 - 1025
反应条件
1: 80 percent / HBr / acetic acid / 2 h / 20 °C 2: 99 percent / 4-dimethylaminopyridine / tetrahydrofuran / 1 h / 20 °C View Scheme
参考文献
Bulletin of the Chemical Society of Japan, , vol. 77, # 5 p. 1021 - 1025
反应条件
1: 85 percent / HBr / acetic acid / 2 h / 20 °C 2: DBU / 3 h / Heating 3: 99 percent / 4-dimethylaminopyridine / tetrahydrofuran / 1 h / 20 °C View Scheme
参考文献
Bulletin of the Chemical Society of Japan, , vol. 77, # 5 p. 1021 - 1025
反应条件
methanol; magnesium T=0°C; 4 h;
参考文献
Kurokawa, Masayuki; Sugai, Takeshi
Bulletin of the Chemical Society of Japan, 2004 , vol. 77, # 5 p. 1021 - 1025
反应条件
5 Pd(II)/C(eggshell); hydrogen in hexafluoroisopropyl alcohol T=50°C; P=5250.53 Torr; 8 h;
参考文献
Organic and Biomolecular Chemistry, , vol. 10, # 32 p. 6587 - 6594
反应条件
1: 92 percent / magnesium; methanol / 4 h / 0 °C 2: 49 percent / Chirazyme L-2 / aq. phosphate buffer / 30 h / 60 °C / pH 7.0 View Scheme
参考文献
Kurokawa, Masayuki; Sugai, Takeshi
Bulletin of the Chemical Society of Japan, 2004 , vol. 77, # 5 p. 1021 - 1025
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran 6 h; Heating;
参考文献
Tetrahedron, , vol. 60, # 44 p. 10039 - 10047
