1,8-diazabicyclo[5.4.0]undec-7-ene in tetrahydrofuran; acetonitrile Cycloaddition; 18 h;

1: 95 percent / HCl(g) / 2 h / Heating 2: 78 percent / K2CO3 / acetonitrile / 0.42 h / Heating 3: 95 percent / NaN3 / dimethylsulfoxide / 16 h / 25 °C 4: H2, HCl(g) / 10percent Pd/C / methanol / 5 h / 2327.2 Torr 5: Et3N / methanol / 1.5 h / Heating View Scheme

1: 78 percent / K2CO3 / acetonitrile / 0.42 h / Heating 2: 95 percent / NaN3 / dimethylsulfoxide / 16 h / 25 °C 3: H2, HCl(g) / 10percent Pd/C / methanol / 5 h / 2327.2 Torr 4: Et3N / methanol / 1.5 h / Heating View Scheme

1: 95 percent / NaN3 / dimethylsulfoxide / 16 h / 25 °C 2: H2, HCl(g) / 10percent Pd/C / methanol / 5 h / 2327.2 Torr 3: Et3N / methanol / 1.5 h / Heating View Scheme

1: H2, HCl(g) / 10percent Pd/C / methanol / 5 h / 2327.2 Torr 2: Et3N / methanol / 1.5 h / Heating View Scheme

1: With hydrogenchloride in methanol 8 h; 2: With 1,8-diazabicyclo[5.4.0]undec-7-ene in acetonitrile T=60°C;

1: With hydrogenchloride in methanol 8 h; 2: With 1,8-diazabicyclo[5.4.0]undec-7-ene in acetonitrile T=60°C;