(1R,2R)-(-)-反式-1-氨基-2-茚醇合成路线 （共 7 条）
反应条件
N-isopropylcarbamoyl-derivatized cyclofructan-6 column in methanol; acetic acid; triethylamine; acetonitrile T=20°C; Resolution of racemate;
参考文献
Analytical Chemistry, , vol. 81, # 24 p. 10215 - 10226
反应条件
water; hydrazine hydrate T=60°C; 3 h; optical yield given as percent ee;
参考文献
Tetrahedron Asymmetry, , vol. 22, # 24 p. 2134 - 2143
反应条件
1: triethylamine / toluene / 3 h / Reflux 2: 4-(N,N-dimethlyamino)pyridine / dichloromethane / 20 °C 3: Arthrobacter sp. lipase / toluene / 25 °C / pH 7 / aq. phosphate buffer; Enzymatic reaction 4: water; hydrazine hydrate / 3 h / 60 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 22, # 24 p. 2134 - 2143
反应条件
1: N-bromosuccinmide; water / tetrahydrofuran 2: triethylamine / toluene / 3 h / Reflux 3: 4-(N,N-dimethlyamino)pyridine / dichloromethane / 20 °C 4: Arthrobacter sp. lipase / toluene / 25 °C / pH 7 / aq. phosphate buffer; Enzymatic reaction 5: water; hydrazine hydrate / 3 h / 60 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 22, # 24 p. 2134 - 2143
反应条件
hydrogenchloride; hydrogen; palladium in methanol 20 h; Ambient temperatureeffect of acid, effect of catalyst, effect of hydrogen pressure, effect of solvent; Product distribution;
参考文献
Bulletin of the Chemical Society of Japan, , vol. 72, # 5 p. 1093 - 1100
反应条件
sodium carbonate in tetrahydrofuran; water
T=0 - 20°C;
参考文献
Probst, Nicolas; Madarasz, Udam; Valkonen, Arto; Papai, Imre; Rissanen, Kari; Neuvonen, Antti; Pihko, Petri M.
Angewandte Chemie - International Edition, 2012 , vol. 51, # 34 p. 8495 - 8499
反应条件
sodium nitrate; trifluoroacetic acid; trifluoroacetic anhydride in dichloromethane
T=-20°C; 5 h; Large scale reaction;
参考文献
Hansen, Marvin M.; Borders, Sandra S.K.; Clayton, Marcella T.; Heath, Perry C.; Kolis, Stanley P.; Larsen, Samuel D.; Linder, Ryan J.; Reutzel-Edens, Susan M.; Smith, Justin C.; Tameze, Sheila L.; Ward, Jeffrey A.; Weigel, Leland O.
Organic Process Research and Development, 2009 , vol. 13, # 2 p. 198 - 208
