1: in tetrahydrofuran T=50°C; 22 h; Inert atmosphere; 2: With potassium carbonate in N,N-dimethyl-formamide T=20°C; 22 h; 3: With potassium tert-butylate in N,N-dimethyl-formamide 2 h;
参考文献
SELEXAGEN THERAPEUTICS, INC.; VERNIER, Jean-michel; HOPKINS, Stephanie; BOUNAUD, Pierre-Yves; O'CONNOR, Patrick; MATTHEWS, David; BENDER, Steve
Patent: WO2012/125981 A2, 2012 ;
Location in patent: Page/Page column 133 ;
WO 2012/125981 A2
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反应条件
ammonium chloride in (2S)-N-methyl-1-phenylpropan-2-amine hydrate; N,N-dimethyl-formamide