1-乙酰基-4-(4-硝基苯基)哌嗪合成路线 （共 8 条）
参考文献
Al-Horani, Rami A.; Mehta, Akul Y.; Desai, Umesh R.
European Journal of Medicinal Chemistry, 2012 , vol. 54, p. 771 - 783
反应条件
in acetonitrile
T=60°C; 15 h;
参考文献
SANOFI
Patent: US2012/277220 A1, 2012 ;
Location in patent: Page/Page column 18-19 ;
反应条件
triethylamine in dichloromethane
T=0°C; 2 h;
参考文献
Katz, H. E.; Schilling, M. L.
Journal of the American Chemical Society, 1989 , vol. 111, # 19 p. 7554 - 7557
反应条件
potassium carbonate in dichloromethane
参考文献
Chen, Li; Ding, Qingjie; Gillespie, Paul; Kim, Kyungjin; Lovey, Allen John; McComas, Warren William; Mullin JR., John Guilfoye; Perrotta, Agostino
Patent: US2002/151554 A1, 2002 ;
反应条件
potassium carbonate in dimethyl sulfoxide
T=100°C; 18 h;
参考文献
CYCLACEL LIMITED
Patent: WO2004/43953 A1, 2004 ;
Location in patent: Page 52 ;
WO 2004/043953 A1
反应条件
palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl in toluene
T=90°C; Hartwig-Buchwald reaction; Inert atmosphere;
参考文献
Nguyen, Thuy; Sakasegawa, Yuji; Doh-Ura, Katsumi; Go, Mei-Lin
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 7 p. 2917 - 2929
反应条件
acetic anhydride; triethylamine in dichloromethane
参考文献
Chapdelaine, Marc; Davenport, Timothy; Haeberlein, Markus; Horchler, Carey; McCauley, John; Pierson, Edward; Sohn, Daniel
Patent: US2004/87575 A1, 2004 ;
US 20040087575 A1
参考文献
Booth, Richard John; Dobrusin, Ellen Myra; Josyula, Vara Prasad Venkata Nagendra; McNamara, Dennis Joseph; Toogood, Peter Laurence
Patent: US2003/73668 A1, 2003 ;
US 20030073668 A1
