1: With potassium hydroxide; water T=120°C; 14 h; 2: With hydrogenchloride; water in diethyl ether Product distribution / selectivity;

hydrogenchloride; sodium hydroxide in toluene

1: With methanol; sodium hydroxide; water T=70 - 80°C; 2 h; 2: With hydrogenchloride; water T=40°C; pH=3.0 - ~ 4.0;

1: 1-(mercaptomethyl)-cyclopropaneacetic acid With sodium hydride in N,N-dimethyl-formamide T=-5°C; 1 h; 2: 2-[2-[(3S)-[3-[(2E)-(7-chloroquinolin-2-yl)ethenyl]phenyl]-3-chloropropyl]phenyl]-2-propanol in N,N-dimethyl-formamide T=-5 - 0°C; 13 h; 3: N,N-dicyclohexylamine in ethyl acetate T=20 - 22°C; 1.75 h;

1: 1-(mercaptomethyl)-cyclopropaneacetic acid With sodium methylate in methanol; dimethyl sulfoxide T=-5 - 0°C; 1 h; 2: (S)-benzenepropanol α-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-2-(1-hydroxy-1-methyl ethyl)-α-methane sulfonate in methanol; water; dimethyl sulfoxide T=-5 - 20°C; 10.5 h; 3: N,N-dicyclohexylamine With sodium hydroxide; acetic acid Product distribution / selectivity; more than 3 stages;

1: 1-(mercaptomethyl)-cyclopropaneacetic acid With n-butyllithium in tetrahydrofuran T=-12.5°C; 0.666667 h; 2: 2-(3-(S)-(3-(2-(7-chloroquinolinyl)ethenyl)phenyl)-3-methanesulfonyloxypropyl)phenyl-2-propanol in tetrahydrofuran T=-2°C; 3.5 h; 3: N,N-dicyclohexylamine in isopropyl alcohol; acetonitrile T=29°C; 15.5 h; Product distribution / selectivity;

1: (S)-1-{3-[(E)-2-(7-chloro-quinolin-2-yl)-vinyl]-phenyl}-3-[2-(1-hydroxy-1-methylethyl)-phenyl]-propan-1-ol With methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine in tetrahydrofuran T=-15 - -10°C; Inert atmosphere; 2: 1-(mercaptomethyl)-cyclopropaneacetic acid With sodium methylate in tetrahydrofuran; methanol; isobutyl methylketone T=-15 - 20°C;

aminoguanidine hydrogen carbonate in tetrahydrofuran T=25 - 45°C;

1: With sodium hydroxide in water; N,N-dimethyl-formamide T=25°C; 2 h; 2: With sodium chloride in water; ethyl acetate; N,N-dimethyl-formamide T=25°C; 0.25 h; 3: With 2,3-dihydroxybutanedioic acid in water; ethyl acetate; N,N-dimethyl-formamide T=25°C; 0.25 h;

1: 1-(mercaptomethyl)-cyclopropaneacetic acid With n-butyllithium in tetrahydrofuran; hexane T=-15°C; 0.5 h; 2: (S)-benzenepropanol α-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-2-(1-hydroxy-1-methyl ethyl)-α-methane sulfonate in tetrahydrofuran; hexane 1 h; Product distribution / selectivity;