1-BOC-4-哌啶丙酸甲酯合成路线 （共 10 条）
反应条件
hydrogen; palladium on activated charcoal in methanol P=2844.3 Torr; 24 h;
参考文献
Klein, Scott I.; Molino, Bruce F.; Czekaj, Mark; Gardner, Charles J.; Chu, Valeria; Brown, Karen; Sabatino, Ralph D.; Bostwick, Jeffrey S.; Kasiewski, Charles; Bentley, Ross; Windisch, Vincent; Perrone, Mark; Dunwiddie, Christopher T.; Leadley, Robert J.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 14 p. 2492 - 2502
反应条件
hydrogen; palladium 10 on activated carbon in methanol P=2585.81 Torr; 15 h;
参考文献
WO2004/58702 A2, ;
Page 35; 21 ;
WO 2004/058702 A2
反应条件
potassium carbonate in DMF (N,N-dimethyl-formamide) T=0 - 20°C;
参考文献
WO2004/92124 A2, ;
Page 83 ;
WO 2004/092124 A2
反应条件
in diethyl ether T=20°C; 1 h;
参考文献
WO2008/141976 A1, ;
Page/Page column 39 ;
WO 2008/141976 A1
反应条件
1: 98 percent / aq. K2CO3 / tetrahydrofuran / 4 h / Ambient temperature 2: 65 percent / Et3N, BOP-Cl / dimethylformamide / 16 h / Ambient temperature 3: 87 percent / LiAlH4 / tetrahydrofuran / 5 h / Ambient temperature 4: 81.5 percent / CHCl3 / 16 h / Heating 5: 100 percent / H2 / 10percent Pd/C / methanol / 24 h / 2844.3 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 41, # 14 p. 2492 - 2502
反应条件
1: 98 percent / aq. K2CO3 / tetrahydrofuran / 4 h / Ambient temperature 2: 65 percent / Et3N, BOP-Cl / dimethylformamide / 16 h / Ambient temperature 3: 87 percent / LiAlH4 / tetrahydrofuran / 5 h / Ambient temperature 4: 81.5 percent / CHCl3 / 16 h / Heating 5: 100 percent / H2 / 10percent Pd/C / methanol / 24 h / 2844.3 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 41, # 14 p. 2492 - 2502
反应条件
1: 65 percent / Et3N, BOP-Cl / dimethylformamide / 16 h / Ambient temperature 2: 87 percent / LiAlH4 / tetrahydrofuran / 5 h / Ambient temperature 3: 81.5 percent / CHCl3 / 16 h / Heating 4: 100 percent / H2 / 10percent Pd/C / methanol / 24 h / 2844.3 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 41, # 14 p. 2492 - 2502
反应条件
1: 87 percent / LiAlH4 / tetrahydrofuran / 5 h / Ambient temperature 2: 81.5 percent / CHCl3 / 16 h / Heating 3: 100 percent / H2 / 10percent Pd/C / methanol / 24 h / 2844.3 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 41, # 14 p. 2492 - 2502
反应条件
1: 81.5 percent / CHCl3 / 16 h / Heating 2: 100 percent / H2 / 10percent Pd/C / methanol / 24 h / 2844.3 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 41, # 14 p. 2492 - 2502
反应条件
sodium hydroxide in methanol 0.5 h; Ambient temperature;
参考文献
Klein, Scott I.; Molino, Bruce F.; Czekaj, Mark; Gardner, Charles J.; Chu, Valeria; Brown, Karen; Sabatino, Ralph D.; Bostwick, Jeffrey S.; Kasiewski, Charles; Bentley, Ross; Windisch, Vincent; Perrone, Mark; Dunwiddie, Christopher T.; Leadley, Robert J.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 14 p. 2492 - 2502
