乙酸-[2-(4-辛基苯基)]乙醇合成路线 （共 15 条）
反应条件
iodine; triphenylphosphine in ether (200 ml)-acetonitrile
参考文献
Yoshitomi Pharmaceutical Industries, Ltd.
Patent: US5948820 A1, 1999 ;
反应条件
1: Et3N / CH2Cl2 / 1 h 2: 5.37 g / LiI / tetrahydrofuran / 4 h / 20 °C View Scheme
参考文献
Kiuchi, Masatoshi; Adachi, Kunitomo; Kohara, Toshiyuki; Minoguchi, Masanori; Hanano, Tokushi; Aoki, Yoshiyuki; Mishina, Tadashi; Arita, Masafumi; Nakao, Noriyoshi; Ohtsuki, Makio; Hoshino, Yukio; Teshima, Koji; Chiba, Kenji; Sasaki, Shigeo; Fujita, Tetsuro
Journal of Medicinal Chemistry, 2000 , vol. 43, # 15 p. 2946 - 2961
反应条件
1.1: Et3N / CH2Cl2 / 1 h / 20 °C 2.1: 16.0 g / NaI / butan-2-one / 2 h / Heating 3.1: sodium ethoxide / ethanol / 0.5 h / 20 °C 3.2: 61 percent / ethanol / 3 h / 65 °C 4.1: LiAlH4 / tetrahydrofuran / 2 h / 20 °C View Scheme
参考文献
Kiuchi, Masatoshi; Adachi, Kunitomo; Kohara, Toshiyuki; Minoguchi, Masanori; Hanano, Tokushi; Aoki, Yoshiyuki; Mishina, Tadashi; Arita, Masafumi; Nakao, Noriyoshi; Ohtsuki, Makio; Hoshino, Yukio; Teshima, Koji; Chiba, Kenji; Sasaki, Shigeo; Fujita, Tetsuro
Journal of Medicinal Chemistry, 2000 , vol. 43, # 15 p. 2946 - 2961
反应条件
1.1: Et3N / CH2Cl2 / 1 h / 20 °C 2.1: 16.0 g / NaI / butan-2-one / 2 h / Heating 3.1: sodium ethoxide / ethanol / 0.5 h / 20 °C 3.2: 61 percent / ethanol / 3 h / 65 °C 4.1: LiAlH4 / tetrahydrofuran / 2 h / 20 °C 5.1: 8.25 g / pyridine / 16 h / 20 °C 6.1: 2 N aq. LiOH / methanol / 2 h / Heating View Scheme
参考文献
Kiuchi, Masatoshi; Adachi, Kunitomo; Kohara, Toshiyuki; Minoguchi, Masanori; Hanano, Tokushi; Aoki, Yoshiyuki; Mishina, Tadashi; Arita, Masafumi; Nakao, Noriyoshi; Ohtsuki, Makio; Hoshino, Yukio; Teshima, Koji; Chiba, Kenji; Sasaki, Shigeo; Fujita, Tetsuro
Journal of Medicinal Chemistry, 2000 , vol. 43, # 15 p. 2946 - 2961
反应条件
1.1: Et3N / CH2Cl2 / 1 h 2.1: 5.37 g / LiI / tetrahydrofuran / 4 h / 20 °C 3.1: NaH / dimethylformamide / 30 h 3.2: 82 percent / dimethylformamide / 1 h / 50 - 60 °C View Scheme
参考文献
Kiuchi, Masatoshi; Adachi, Kunitomo; Kohara, Toshiyuki; Minoguchi, Masanori; Hanano, Tokushi; Aoki, Yoshiyuki; Mishina, Tadashi; Arita, Masafumi; Nakao, Noriyoshi; Ohtsuki, Makio; Hoshino, Yukio; Teshima, Koji; Chiba, Kenji; Sasaki, Shigeo; Fujita, Tetsuro
Journal of Medicinal Chemistry, 2000 , vol. 43, # 15 p. 2946 - 2961
