2,4-二氯噻吩并[3,2-d]嘧啶合成路线

参考文献

Verheijen, Jeroen C.; Yu, Ker; Toral-Barza, Lourdes; Hollander, Irwin; Zask, Arie
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 1 p. 375 - 379

22288-78-43-氨基-2-噻吩甲酸甲酯

16234-14-32,4-二氯噻吩并[3,2-d]嘧啶+

16233-51-51,3-二氢噻吩并[3,2-d]嘧啶-2,4-二酮

参考文献

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22288-78-43-氨基-2-噻吩甲酸甲酯

16234-14-32,4-二氯噻吩并[3,2-d]嘧啶

参考文献

WO2011/130628 A1, ;
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22288-78-43-氨基-2-噻吩甲酸甲酯+

57-13-6尿素

16234-14-32,4-二氯噻吩并[3,2-d]嘧啶

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Bioorganic and Medicinal Chemistry Letters, , vol. 20, # 8 p. 2408 - 2411

16234-14-32,4-二氯噻吩并[3,2-d]嘧啶

885618-31-52-氯-4-(4-吗啉)-噻吩并[3,2-d]嘧啶-6-羧醛

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Zhu, Wu Fu; Zhai, Xin; Li, Sai; Cao, Yun Yun; Gong, Ping; Liu, Ya Jing
Chinese Chemical Letters, 2012 , vol. 23, # 6 p. 703 - 706

16234-14-32,4-二氯噻吩并[3,2-d]嘧啶

957054-30-74-羟基-2,6-二甲基苯甲腈

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16234-14-32,4-二氯噻吩并[3,2-d]嘧啶

1119280-68-02-氯噻吩并[3,2-d]嘧啶

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GATEKEEPER PHARMACEUTICAL, INC.; GRAY, Nathanael, S.; ZHOU, Wenjun
Patent: WO2011/79231 A1, 2011 ;
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110-91-8吗啉+

16234-14-32,4-二氯噻吩并[3,2-d]嘧啶

16234-15-42-氯-4-(4-吗啉基)噻吩并[3,2-D]嘧啶

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GENENTECH, INC.; PIRAMED LIMITED
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WO 2007/127183 A1

16234-14-32,4-二氯噻吩并[3,2-d]嘧啶

1245811-20-4

参考文献

Deng, Jifeng; Peng, Li; Zhang, Guicheng; Lan, Xiaobing; Li, Chufang; Chen, Fuxin; Zhou, Yayao; Lin, Zuoxian; Chen, Ling; Dai, Renke; Xu, Hongjiang; Yang, Ling; Zhang, Xiquan; Hu, Wenhui
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16234-14-32,4-二氯噻吩并[3,2-d]嘧啶

1152475-42-77-溴-2-氯噻吩并[3,2-d]嘧啶

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GATEKEEPER PHARMACEUTICAL, INC.; GRAY, Nathanael, S.; ZHOU, Wenjun
Patent: WO2011/79231 A1, 2011 ;