4-羟基噻吩并[3,2-d]嘧啶合成路线 （共 28 条）
反应条件
ammonium formate; formamide T=140°C; 10 h;
参考文献
ARRAY BIOPHARMA INC.
Patent: WO2005/51304 A2, 2005 ;
Location in patent: Page/Page column 67-68 ;
WO 2005/051304 A2
反应条件
ammonia in methanol T=130°C; 7 h;
参考文献
Ube Industries, Ltd.
Patent: EP1637523 A1, 2006 ;
Location in patent: Page/Page column 9 ;
反应条件
1: formic acid With acetic anhydride 2: methyl 3-aminothiophene-2-carboxylate T=20°C; 3 h; 3: With ammonium formate in formamide T=20 - 150°C; 20 h;
参考文献
HANMI PHARM. CO., LTD.; BANG, Keuk Chan; PARK, Chang Hee; CHOI, Jae Yul; KIM, Seo Hee; HAM, Young Jin
Patent: WO2014/3483 A1, 2014 ;
Location in patent: Page/Page column 19 ;
反应条件
ammonium formate in formamide
参考文献
Board of Regents, The University of Texas System
Patent: US6503914 B1, 2003 ;
反应条件
ammonium formate in formamide
参考文献
Board of Regents, The University of Texas System
Patent: US6503914 B1, 2003 ;
反应条件
1: formic acid; methyl 3-aminothiophene-2-carboxylate With acetic anhydride T=20°C; 3 h; 2: ammonium formate; formamide T=20 - 150°C; 20 h;
参考文献
HANMI PHARM CO., LTD.; BAE, In Hwan; SON, Jung Beom; HAN, Sang Mi; KWAK, Eun Joo; KIM, Ho Seok; SONG, Ji Young; BYUN, Eun Young; JUN, Seung Ah; AHN, Young Gil; SUH, Kwee Hyun
Patent: WO2013/100632 A1, 2013 ;
Location in patent: Page/Page column 28 ;
参考文献
MethylGene, Inc.
Patent: US2005/288282 A1, 2005 ;
反应条件
formamide in dichloromethane
参考文献
Warner-Lambert Company
Patent: US5654307 A1, 1997 ;
US 5654307 A
参考文献
WO2011/93684 A2, ;
Page/Page column 17; 18 ;
WO 2011/093684 A1
反应条件
in 2-methoxy-ethanol 3 h; Heating / reflux;
参考文献
US2003/225111 A1, ;
Page 50, 51 ;
