1,5-二氢-3-异丙基-8-甲基-[1,3]二氧杂卓并[5,6-c]吡啶-9-醇合成路线 （共 7 条）
反应条件
1: With water; acetic acid in tetrahydrofuran T=60°C; P=760.051 Torr; 4 h; 2: With hydrogenchloride; water in tetrahydrofuran T=0 - 60°C; 5 h; Product distribution / selectivity;
参考文献
BASF AKTIENGESELLSCHAFT
Patent: WO2004/58774 A1, 2004 ;
Location in patent: Page/Page column 20 ;
反应条件
1: With acetic acid in tetrahydrofuran T=60°C; P=760.051 Torr; 2.5 h; 2: With hydrogenchloride in tetrahydrofuran T=20 - 60°C; 5 h; Product distribution / selectivity;
参考文献
BASF AKTIENGESELLSCHAFT
Patent: WO2004/58774 A1, 2004 ;
Location in patent: Page/Page column 19 ;
反应条件
T=90 - 155°C; Diels-Alder Reaction; P=112.511 - 760.051 Torr; 4 - 24 h; Product distribution / selectivity;
参考文献
DSM IP ASSETS B.V.
Patent: WO2005/49618 A1, 2005 ;
Location in patent: Page/Page column 12-14 ;
参考文献
L'vova,S.D. et al.
Pharmaceutical Chemistry Journal, 1978 , vol. 12, # 12 p. 1636 - 1638
Khimiko-Farmatsevticheskii Zhurnal, 1978 , vol. 12, # 12 p. 106 - 109
反应条件
hydrogenchloride; water P=300.03 Torr; 2 h; Heating / reflux; Product distribution / selectivity;
参考文献
BASF AKTIENGESELLSCHAFT
Patent: WO2004/58774 A1, 2004 ;
Location in patent: Page/Page column 18-19 ;
反应条件
(i) NaH, DMSO, (ii) /BRN= 605309/; Multistep reaction;
参考文献
Bruhn,J. et al.
Helvetica Chimica Acta, 1978 , vol. 61, p. 2542 - 2559
参考文献
DSM IP ASSETS B.V.
Patent: WO2005/49618 A1, 2005 ;
Location in patent: Page/Page column 15 ;
