吡唑并[1,5-a]吡啶-3-羧酸合成路线 （共 6 条）
反应条件
sodium hydroxide 1) water, 30 min, reflux, 2) 95percent ethanol, 20 min, reflux, 3) HCl;
参考文献
Anderson, Paul L.; Hasak, James P; Kahle, Alicia D.; Paolella, Nicholas A.; Shapiro, Michael J.
Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 1149 - 1152
反应条件
1: 1.) (COCl)2 / 1.) toluene, from RT to 60 deg C, 4.5 h, 2.) CH2Cl2, from -60 deg C to RT, 2 h 2: 71 percent / LiAlH4 / diethyl ether / 2 h / Heating View Scheme
参考文献
Loeber, Stefan; Huebner, Harald; Gmeiner, Peter
Bioorganic & Medicinal Chemistry Letters, 1999 , vol. 9, # 1 p. 97 - 102
参考文献
Qiao, Lixin; Choi, Sungwoon; Case, April; Gainer, Thomas G.; Seyb, Kathleen; Glicksman, Marcie A.; Lo, Donald C.; Stein, Ross L.; Cuny, Gregory D.
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 21 p. 6122 - 6126
参考文献
Anderson, Paul L.; Hasak, James P; Kahle, Alicia D.; Paolella, Nicholas A.; Shapiro, Michael J.
Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 1149 - 1152
反应条件
N-bromosuccinmide; sodium hydrogencarbonate in N,N-dimethyl-formamide T=20°C; 4 h;
参考文献
ALMIRALL, S.A.; BACH TANA, Jordi; PAGES SANTACANA, Lluis, Miquel; TALTAVULL MOLL, Joan; EASTWOOD, Paul, Robert; GONZALEZ RODRIGUES, Jacob; GIULIO MATASSA, Victor
Patent: WO2011/101161 A1, 2011 ;
Location in patent: Page/Page column 99 ;
WO 2011/101161 A1
反应条件
1: sodium hydrogencarbonate; N-bromosuccinmide / N,N-dimethyl-formamide / 4 h / 20 °C 2: potassium carbonate; tri-cyclo-hexyl-phosphine / palladium diacetate / water; diethylene glycol dimethyl ether / 2 h / 100 °C View Scheme
参考文献
Bethel, Paul A.; Campbell, Andrew D.; Goldberg, Frederick W.; Kemmitt, Paul D.; Lamont, Gillian M.; Suleman, Abid
Tetrahedron, 2012 , vol. 68, # 27-28 p. 5434 - 5444
