1-苯基-2-(4-吡啶)乙酮合成路线 （共 44 条）
反应条件
1: ethanolic KOH-solution
2: sulfuric acid; water
View Scheme
参考文献
Smith et al.
Journal of the American Chemical Society, 1948 , vol. 70, p. 3997,3998
反应条件
aluminium trichloride in carbon disulfide
0.5 h; Ambient temperature;
参考文献
Ogata, Masaru; Matsumoto, Hiroshi; Kida, Shiro; Shimizu, Sumio; Tawara, Katsuya; Kawamura, Yoshimi
Journal of Medicinal Chemistry, 1987 , vol. 30, # 8 p. 1497 - 1502
反应条件
methanesulfonic acid; phosphorus pentoxide
T=50 - 60°C;
参考文献
Clader, John W.; Berger, Joel G.; Burrier, Robert E.; Davis, Harry R.; Domalski, Martin; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 10 p. 1600 - 1607
参考文献
Konakahara, Takeo; Kurosaki, Yoshihiro
Journal of Chemical Research, Miniprint, 1989 , # 5 p. 1068 - 1086
反应条件
2: 65 percent / acetonitrile
3: 32 percent / O2 / CH2Cl2 / 168 h
View Scheme
参考文献
Akiba, Kin-ya; Nishihara, Yoshihiro; Wada, Makoto
Tetrahedron Letters, 1983 , vol. 24, # 47 p. 5269 - 5272
反应条件
1: 86 percent / tetrabutylammonium fluoride
2: 32 percent / O2 / CH2Cl2 / 168 h
View Scheme
参考文献
Akiba, Kin-ya; Nishihara, Yoshihiro; Wada, Makoto
Tetrahedron Letters, 1983 , vol. 24, # 47 p. 5269 - 5272
反应条件
1: diisopropylamin, n-butyllithium (15 percent) / hexane; tetrahydrofuran / 1 h / -78 °C
2: tetrabutylammoniumfluorid-hydrat / hexane; tetrahydrofuran; CH2Cl2 / 2 h / Ambient temperature
View Scheme
参考文献
Klose, Walter; Schwarz, Katica
Journal of Heterocyclic Chemistry, 1985 , vol. 22, p. 669 - 671
反应条件
1: diisopropylamin, n-butyllithium (15 percent) / hexane; tetrahydrofuran / 1 h / -78 °C
2: tetrabutylammoniumfluorid-hydrat / hexane; tetrahydrofuran; CH2Cl2 / 2 h / Ambient temperature
View Scheme
参考文献
Klose, Walter; Schwarz, Katica
Journal of Heterocyclic Chemistry, 1985 , vol. 22, p. 669 - 671
反应条件
water; hydrogen bromide
T=180°C; unter Druck;
参考文献
Kroehnke et al.
Justus Liebigs Annalen der Chemie, 1956 , vol. 600, p. 176,188
反应条件
1: 1.) LDA / 1.) hexane, THF, -78 deg C, 10 min, 2.) -78 deg C, 15 min
2: azobisisobutyronitrile / CCl4 / 16 h / Heating
View Scheme
参考文献
Lee, Cheuk Man; Sammes, Michael P.; Katritzky, Alan R.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 2458 - 2462
