1-苯基-2-吡啶-2-基乙酮合成路线 （共 47 条）
反应条件
1: 2-picoline With n-butyllithium in tetrahydrofuran; hexane T=-10°C; Inert atmosphereSchlenk technique; 2: benzonitrile in tetrahydrofuran; hexane T=-40°C; Inert atmosphere;
参考文献
Graser, Markus; Kopacka, Holger; Wurst, Klaus; Mueller, Thomas; Bildstein, Benno
Inorganica Chimica Acta, 2013 , vol. 401, p. 38 - 49
反应条件
1: 2-picoline With lithium diisopropyl amide in tetrahydrofuran T=-78°C; 0.166667 h; 2: benzonitrile in tetrahydrofuran T=-78 - 20°C; 3 h; 3: With hydrogenchloride; sodium hydroxide; water; ammonium chloride more than 3 stages;
参考文献
WO2007/31747 A1, ;
Page/Page column 29 ;
WO 2007/031747 A1
反应条件
1: in diethyl ether T=20°C; 2 h; 2: With sulfuric acid; water in diethyl ether 0.5 h; Heating / reflux;
参考文献
WO2004/11410 A1, ;
Page 80-81 ;
WO 2004/011410 A1
反应条件
samarium diiodide; potassium tert-butylate in tetrahydrofuran; dimethyl sulfoxide 0.25 h;
参考文献
Nazareno, Monica A.; Rossi, Roberto A.
Tetrahedron Letters, 1994 , vol. 35, # 29 p. 5185 - 5188
反应条件
1: 2-picoline With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 0.5 h; Inert atmosphere; 2: N-Methoxy-N-methyl-benzamide in tetrahydrofuran; hexane T=-78°C; 3 h; Inert atmosphere;
参考文献
Muir, Calum W.; Kennedy, Alan R.; Redmond, Joanna M.; Watson, Allan J. B.
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 20 p. 3337 - 3340
反应条件
n-butyllithium; anhydrous sodium hydrogen carbonate; acetic acid in tetrahydrofuran; hexane; ethyl acetate
反应条件
1: diethyl pyrydin-2’-ylmethyl phosphate With manganese in tetrahydrofuran T=20°C; 8 h; 2: benzoyl chloride in tetrahydrofuran T=20°C; 1 h;
参考文献
Suh, YoungSung; Lee, Jun-Sik; Kim, Seoung-Hoi; Rieke, Reuben D.
Journal of Organometallic Chemistry, 2003 , vol. 684, # 1-2 p. 20 - 36
反应条件
diethyl ether; ammonia; KNH2 und anschliessend mit Aethylbenzoat in Aether;
参考文献
Journal of Organic Chemistry, , vol. 15, p. 1,4
Journal of the American Chemical Society, , vol. 71, p. 2026
反应条件
samarium diiodide; potassium tert-butylate in tetrahydrofuran; dimethyl sulfoxide 0.5 h;
参考文献
Nazareno, Monica A.; Rossi, Roberto A.
Tetrahedron Letters, 1994 , vol. 35, # 29 p. 5185 - 5188
