4-甲基-联苯-2-甲醛合成路线 （共 29 条）
反应条件
1: 88 percent / 4.5 N aq. HCl / 12 h / Heating 2: 1.) acetyl chloride / 1.) 0 deg C, 0.25 h, 2.) reflux, 4 h 3: 42.55 g / diisobutylaluminum hydride / toluene / 0.25 h / -78 - -70 °C 4: pyridinium chlorochromate / CH2Cl2 / 0.5 h / 25 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 8 p. 2525 - 2547
反应条件
1: 95 percent / thionyl chloride / 18 h / 20 °C 2: CH2Cl2 / 2 h / 20 °C 3: thionyl chloride / 1 h / 25 °C 4: tetrahydrofuran / 2 h / 20 °C 5: 88 percent / 4.5 N aq. HCl / 12 h / Heating 6: 1.) acetyl chloride / 1.) 0 deg C, 0.25 h, 2.) reflux, 4 h 7: 42.55 g / diisobutylaluminum hydride / toluene / 0.25 h / -78 - -70 °C 8: pyridinium chlorochromate / CH2Cl2 / 0.5 h / 25 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 8 p. 2525 - 2547
反应条件
1: CH2Cl2 / 2 h / 20 °C 2: thionyl chloride / 1 h / 25 °C 3: tetrahydrofuran / 2 h / 20 °C 4: 88 percent / 4.5 N aq. HCl / 12 h / Heating 5: 1.) acetyl chloride / 1.) 0 deg C, 0.25 h, 2.) reflux, 4 h 6: 42.55 g / diisobutylaluminum hydride / toluene / 0.25 h / -78 - -70 °C 7: pyridinium chlorochromate / CH2Cl2 / 0.5 h / 25 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 8 p. 2525 - 2547
反应条件
1: sodium sulfate / tetrahydrofuran / 24 h / 20 °C / |Schlenk technique; |Inert atmosphere 2: potassium hydroxide; palladium diacetate; dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine / neat (no solvent) / 24 h / 110 °C / |Schlenk technique; |Inert atmosphere View Scheme
参考文献
Advanced Synthesis and Catalysis, , vol. 355, # 18 p. 3553 - 3557
参考文献
Bulletin de la Societe Chimique de France, , p. 3238 - 3243
反应条件
multistep reaction; reactions of derivatives with var. arylhalides; Product distribution;
参考文献
Tetrahedron Letters, , vol. 35, # 28 p. 5039 - 5042
反应条件
N-bromosuccinmide; dibenzoyl peroxide in dichloromethane 5 h; Heating / reflux;
参考文献
LEK PHARMACEUTICALS D.D.
Patent: WO2006/103068 A1, 2006 ;
Location in patent: Page/Page column 6; 14 ;
WO 2006/103068 A1
反应条件
tert.-butylhydroperoxide; biscyclopentadienyliron(II) in decane; acetonitrile
T=20 - 90°C; 24 h; SolventReagent/catalystTemperature;
参考文献
Wertz, Sebastian; Leifert, Dirk; Studer, Armido
Organic Letters, 2013 , vol. 15, # 4 p. 928 - 931
