4'-溴-2,2,2-三氟苯乙酮合成路线 （共 23 条）
反应条件
hydrogenchloride in tetrahydrofuran; diethyl ether; ethanol; hexane
反应条件
1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione in ethyl acetate 20 h; Reflux;
参考文献
Cheng, Huicheng; Pei, Yu; Leng, Faqiang; Li, Jingya; Liang, Apeng; Zou, Dapeng; Wu, Yangjie; Wu, Yusheng
Tetrahedron Letters, 2013 , vol. 54, # 33 p. 4483 - 4486
反应条件
1: p-bromophenyl bromide With magnesium in diethyl ether 2: ethyl-α,α,α-trifluoroacetate in diethyl ether T=-78 - 20°C; 16 h; Further stages.;
参考文献
Bender, Tobias; Huss, Markus; Wieczorek, Helmut; Grond, Stephanie; Von Zezschwitz, Paultheo
European Journal of Organic Chemistry, 2007 , # 23 p. 3870 - 3878
反应条件
hydrogenchloride in tetrahydrofuran; n-butyllithium; diethyl ether
参考文献
BRISTOL-MYERS SQUIBB COMPANY
Patent: EP768305 A1, 1997 ;
EP 0768305 A1
反应条件
1: (trifluoromethyl)-trimethylsilane With silver monofluoride T=20°C; 2 h; 2: 4-bromo-benzoyl chloride With 4-(N,N-dimethlyamino)pyridine in dichloromethane T=20°C; 48 h; Further stages.;
参考文献
Kremlev, Mikhail M.; Mushta, Aleksej I.; Tyrra, Wieland; Naumann, Dieter; Fischer, Hendrik T.M.; Yagupolskii, Yurii L.
Journal of Fluorine Chemistry, 2007 , vol. 128, # 11 p. 1385 - 1389
反应条件
in diethyl ether T=-78 - 20°C;
参考文献
Creary, Xavier
Journal of Organic Chemistry, 1987 , vol. 52, # 22 p. 5026 - 5030
反应条件
n-butyllithium in tetrahydrofuran; hexane T=-78°C; 2.5 h; Inert atmosphere;
参考文献
Journal of the American Chemical Society, , vol. 135, # 14 p. 5364 - 5367
反应条件
1: p-bromophenyl bromide With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 2 h; 2: N-(trifluoroacetyl)piperidine in tetrahydrofuran; hexane T=-78 - 20°C; 3 h;
参考文献
Angewandte Chemie - International Edition, , vol. 52, # 52 p. 14191 - 14195
Angew. Chem., , vol. 125, # 52 p. 14441 - 14445,5
反应条件
1.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C 1.2: 4 h / |Acidic conditions 2.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / 20 h / |Reflux View Scheme
参考文献
Tetrahedron Letters, , vol. 54, # 33 p. 4483 - 4486
参考文献
Bulletin of the Chemical Society of Japan, , vol. 63, # 4 p. 1129 - 1137
