4-(4-甲基哌嗪)苯胺合成路线 （共 19 条）
参考文献
Agouron Pharmaceuticals, Inc.
Patent: EP1215208 A2, 2002 ;
Location in patent: Example C(70) ;
EP 1215208 A2
反应条件
1: 2-allyl-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-6-(methylthio)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one With 3-chloro-benzenecarboperoxoic acid in toluene 0.333333 h; 2: 4-(4-methyl-piperazin-1-yl)-phenylamine With N-ethyl-N,N-diisopropylamine in toluene
参考文献
MERCK and CO., INC.; BANYU PHARMACEUTICAL CO., LTD.
Patent: WO2008/133866 A1, 2008 ;
Location in patent: Page/Page column 32 ;
WO 2008/133866 A1
反应条件
1: 2-allyl-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-6-(methylthio)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one With 3-chloro-benzenecarboperoxoic acid in water; toluene 0.333333 h; 2: 4-(4-methyl-piperazin-1-yl)-phenylamine With N-ethyl-N,N-diisopropylamine in water; toluene
参考文献
Sagara, Takeshi; Otsuki, Sachie; Sunami, Satoshi; Sakamoto, Toshihiro; Niiyama, Kenji; Yamamoto, Fuyuki; Yoshizumi, Takashi; Furuyama, Hidetomo; Goto, Yasuhiro; Bamba, Makoto; Takahashi, Keiji; Hirai, Hiroshi; Nishibata, Toshihide
Patent: US2007/254892 A1, 2007 ;
Location in patent: Page/Page column 51 ;
US 20070254892 A1
参考文献
Wurster, Siegfried; Engstrom, Mia; Savola, Juha-Matti; Hoglund, Iisa; Sallinen, Jukka; Haapalinna, Antti; Tauber, Andrei Yurievitch; Hoffren, Anna-Marja Katariina; Salo, Harri Elias
Patent: US2001/46991 A1, 2001 ;
反应条件
1: trifluoroacetic acid / Sec-butyl alcohol / 100 °C 2: platinum(IV) oxide; hydrogen / methanol 3: N-ethyl-N,N-diisopropylamine / dichloromethane View Scheme
参考文献
Zhou, Wenjun; Ercan, Dalia; Jaenne, Pasi A.; Gray, Nathanael S.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 2 p. 638 - 643
参考文献
Richard, David J.; Verheijen, Jeroen C.; Curran, Kevin; Kaplan, Joshua; Toral-Barza, Lourdes; Hollander, Irwin; Lucas, Judy; Yu, Ker; Zask, Arie
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 24 p. 6830 - 6835
反应条件
hydrogenchloride in methanol; dichloromethane
参考文献
Wurster, Siegfried; Engstrom, Mia; Savola, Juha-Matti; Hoglund, Iisa; Sallinen, Jukka; Haapalinna, Antti; Tauber, Andrei Yurievitch; Hoffren, Anna-Marja Katariina; Salo, Harri Elias
Patent: US2001/46991 A1, 2001 ;
反应条件
triethylamine in dichloromethane
T=20°C; 0.5 h;
参考文献
Wu, Lixin; Lu, Meiqi; Yan, Zhihui; Tang, Xiaobin; Sun, Bo; Liu, Wei; Zhou, Honggang; Yang, Cheng
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 8 p. 2416 - 2426
反应条件
1: With acetic acid
T=100°C; 2.5 h;
2: With sodium hydroxide in water
参考文献
TARGEGEN, INC.
Patent: WO2007/53452 A1, 2007 ;
Location in patent: Page/Page column 104 ;
WO 2007/053452 A1
