3',6'-二羟基苯并降冰片烯合成路线 （共 11 条）
反应条件
palladium on activated charcoal; hydrogen in methanol
T=20°C; P=760.051 Torr; 1.5 h;
参考文献
SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Yingjun; ZHANG, Jiancun; XIE, Hongming; REN, Qingyun; TAN, Yumei; LUO, Huichao
Patent: WO2014/19344 A1, 2014 ;
Location in patent: Paragraph 0341 ;
反应条件
triethylamine in methanol
T=10°C; 5 h;
参考文献
Klaerner, Frank-Gerrit; Panitzky, Jens; Blaeser, Dieter; Boese, Roland
Tetrahedron, 2001 , vol. 57, # 17 p. 3673 - 3687
反应条件
in xylene
26 h; Heating;
参考文献
Mehta, Goverdhan; Karra, Srinivasa Rao
Journal of Organic Chemistry, 1989 , vol. 54, # 12 p. 2975 - 2978
反应条件
silica gel in diethyl ether
0.0833333 h; Ambient temperature;
参考文献
Mebane, Robert C.; Schuster, Gary B.
Journal of Organic Chemistry, 1983 , vol. 48, # 6 p. 810 - 812
反应条件
1: 46 percent / aq. NaOH (50percent), tri-n-butylamine / CH2Cl2 / 16 h / 50 °C
2: 21 percent / tetramethylethylenediamine, lithium bromide/methyl lithium / diethyl ether / 0.5 h / -78 °C
3: tetraphenylporphyrin, O2 / CS2 / 0.07 h / Ambient temperature; Irradiation
4: silica gel / diethyl ether / 0.08 h / Ambient temperature
View Scheme
参考文献
Mebane, Robert C.; Schuster, Gary B.
Journal of Organic Chemistry, 1983 , vol. 48, # 6 p. 810 - 812
反应条件
1: tetraphenylporphyrin, O2 / CS2 / 0.07 h / Ambient temperature; Irradiation
2: silica gel / diethyl ether / 0.08 h / Ambient temperature
View Scheme
参考文献
Mebane, Robert C.; Schuster, Gary B.
Journal of Organic Chemistry, 1983 , vol. 48, # 6 p. 810 - 812
反应条件
1: dichloromethane / 1.5 h / -10 - 20 °C
2: sodium acetate; methanol / 3 h / 50 °C / |Inert atmosphere
3: palladium on activated charcoal; hydrogen / methanol / 1.5 h / 20 °C / 760.05 Torr
View Scheme
参考文献
SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Yingjun; ZHANG, Jiancun; XIE, Hongming; REN, Qingyun; TAN, Yumei; LUO, Huichao
Patent: WO2014/19344 A1, 2014 ;
反应条件
1: sodium acetate; methanol / 3 h / 50 °C / |Inert atmosphere
2: palladium on activated charcoal; hydrogen / methanol / 1.5 h / 20 °C / 760.05 Torr
View Scheme
参考文献
SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Yingjun; ZHANG, Jiancun; XIE, Hongming; REN, Qingyun; TAN, Yumei; LUO, Huichao
Patent: WO2014/19344 A1, 2014 ;
反应条件
1: dichloromethane / 1.5 h / -10 - 20 °C
2: sodium acetate; methanol / 3 h / 50 °C / |Inert atmosphere
3: palladium on activated charcoal; hydrogen / methanol / 1.5 h / 20 °C / 760.05 Torr
View Scheme
参考文献
SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Yingjun; ZHANG, Jiancun; XIE, Hongming; REN, Qingyun; TAN, Yumei; LUO, Huichao
Patent: WO2014/19344 A1, 2014 ;
反应条件
ethanol; palladium
Hydrogenation;
参考文献
Diels; Blom; Koll
Justus Liebigs Annalen der Chemie, 1925 , vol. 443, p. 247
