2-甲基-1,2,3,4-四氢异喹啉合成路线 （共 65 条）
反应条件
1: 1) PH3(+)*BF4(1-) / 1) MeCN, 20 deg C, 3 h, 2) MeCN, 20 deg C, 20 min
2: 100 percent / tetrahydrofuran / 0.03 h / 0 °C
View Scheme
参考文献
De Costa; Radesca
Synthesis, 1992 , # 9 p. 887 - 890
参考文献
v.Braun; Weissbach
Chemische Berichte, 1930 , vol. 63, p. 489,492
反应条件
1: 3 percent Spectr. / diethyl ether / 1 h / 20 °C
2: 71 percent / triethylamine / CH2Cl2 / 12 h / 20 °C
View Scheme
参考文献
Lemoucheux, Laurent; Rouden, Jacques; Ibazizene, Meziane; Sobrio, Franck; Lasne, Marie-Claire
Journal of Organic Chemistry, 2003 , vol. 68, # 19 p. 7289 - 7297
参考文献
Judin et al.
Zhurnal Obshchei Khimii, 1957 , vol. 27, p. 3021,3024; engl. Ausg. S. 3051, 3053
反应条件
in chloroform
Heating;
参考文献
Manoharan, T. Samuel; Madyastha, K. Madhava; Singh, B. B.; Bhatnagar, S. P.; Weiss, Ulrich
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1984 , vol. 23, # 1 p. 5 - 11
反应条件
in chloroform
Heating;
参考文献
Manoharan, T. Samuel; Madyastha, K. Madhava; Singh, B. B.; Bhatnagar, S. P.; Weiss, Ulrich
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1984 , vol. 23, # 1 p. 5 - 11
反应条件
1: concentrated H2SO4; HNO3 / Hydrierung des Reaktionsprodukts an Palladium/Kohle in Aethanol
2: sulfuric acid; sodium nitrite; water
View Scheme
参考文献
Ochiai; Nakagome
Chemical and Pharmaceutical Bulletin, 1958 , vol. 6, p. 497,500
反应条件
1: 3 percent Spectr. / diethyl ether / 1 h / 20 °C
2: 95 percent / CH2Cl2 / 12 h / 20 °C
View Scheme
参考文献
Lemoucheux, Laurent; Rouden, Jacques; Ibazizene, Meziane; Sobrio, Franck; Lasne, Marie-Claire
Journal of Organic Chemistry, 2003 , vol. 68, # 19 p. 7289 - 7297
反应条件
1: CHCl3 / Heating
2: 70 percent / sodium thiophenoxide / acetonitrile; butan-2-one / Heating
View Scheme
参考文献
Manoharan, T. Samuel; Madyastha, K. Madhava; Singh, B. B.; Bhatnagar, S. P.; Weiss, Ulrich
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1984 , vol. 23, # 1 p. 5 - 11
反应条件
1: 1.) n-BuLu, 2.) Et3N / 1.) THF, -50 deg C -> -40 deg C, 1 h, 2.) -50 deg C -> -40 deg C. 0.5 h; room temperature, 2 h
3: methyl acrylate, n-Bu4NF / acetonitrile / 2 h / Ambient temperature
View Scheme
参考文献
Ito; Nakatsuka; Saegusa
Journal of the American Chemical Society, 1982 , vol. 104, # 26 p. 7609 - 7622
