2-甲基-1,2,3,4-四氢异喹啉合成路线 （共 65 条）
反应条件
1: toluene / 0 - 20 °C / Inert atmosphere
2: lithium aluminium tetrahydride / tetrahydrofuran / Inert atmosphere; Reflux
View Scheme
参考文献
Allen, Julia M.; Lambert, Tristan H.
Journal of the American Chemical Society, 2011 , vol. 133, # 5 p. 1260 - 1262
反应条件
1.1: n-butyllithium / hexane; tetrahydrofuran / 2 h / 0 °C / |Inert atmosphere
1.2: Wittig Olefination / 19 h / 0 - 20 °C / |Inert atmosphere
2.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 °C / |Inert atmosphere
2.2: 2 h / -78 - 20 °C / |Inert atmosphere
3.1: water; methanol / 4 h / 20 °C
4.1: sodium tetrahydroborate / 1 h / 0 - 20 °C
5.1: iPr-BOX; n-butyllithium; diisopropylamine / hexane; toluene / 1 h / -78 - -20 °C / |Inert atmosphere
View Scheme
参考文献
Ogata, Tokutaro; Kimachi, Tetsutaro; Yamada, Ken-Ichi; Yamamoto, Yasutomo; Tomioka, Kiyoshi
Heterocycles, 2012 , vol. 86, # 1 p. 469 - 485
反应条件
1.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 °C / |Inert atmosphere
1.2: 2 h / -78 - 20 °C / |Inert atmosphere
2.1: water; methanol / 4 h / 20 °C
3.1: sodium tetrahydroborate / 1 h / 0 - 20 °C
4.1: iPr-BOX; n-butyllithium; diisopropylamine / hexane; toluene / 1 h / -78 - -20 °C / |Inert atmosphere
View Scheme
参考文献
Ogata, Tokutaro; Kimachi, Tetsutaro; Yamada, Ken-Ichi; Yamamoto, Yasutomo; Tomioka, Kiyoshi
Heterocycles, 2012 , vol. 86, # 1 p. 469 - 485
反应条件
1: water; methanol / 4 h / 20 °C
2: sodium tetrahydroborate / 1 h / 0 - 20 °C
3: iPr-BOX; n-butyllithium; diisopropylamine / hexane; toluene / 1 h / -78 - -20 °C / |Inert atmosphere
View Scheme
参考文献
Ogata, Tokutaro; Kimachi, Tetsutaro; Yamada, Ken-Ichi; Yamamoto, Yasutomo; Tomioka, Kiyoshi
Heterocycles, 2012 , vol. 86, # 1 p. 469 - 485
反应条件
2: LiAlH4
View Scheme
参考文献
Kitane, Said; Tshiamala, Kabula; Laude, Bernard; Vebrel, Joeel; Cerutti, Ernest
Tetrahedron, 1985 , vol. 41, # 18 p. 3737 - 3751
反应条件
n-butyllithium
1.) THF, hexane, -50 deg C, 0.5 h, 2.) THF, hexane, from -50 deg C to RT, 3 h; Yield given. Multistep reaction;
参考文献
Almena, Juan; Foubelo, Francisco; Yus, Miguel
Tetrahedron, 1996 , vol. 52, # 25 p. 8545 - 8564
反应条件
4-methyl-morpholine; lithium aluminium tetrahydride; N-ethyl-N,N-diisopropylamine; Wang resin
1.) 0 deg C, 2 h; room temp., overnight, 2.) DMF, room temp., overnight, 3.) THF, 60 deg C, 14 h; Yield given. Multistep reaction;
参考文献
Ho, Chih Y.; Kukla, Michael J.
Tetrahedron Letters, 1997 , vol. 38, # 16 p. 2799 - 2802
反应条件
formic acid
RefluxLarge scale reaction;
参考文献
Kim, Junwon; Jo, Mina; So, Wonyoung; No, Zaesung
Tetrahedron Letters, 2009 , vol. 50, # 11 p. 1229 - 1235
反应条件
in water; acetonitrile
T=25°C; pH 7.0; Rate constant;
参考文献
Bunting, John W.; Chew, Vivian S. F.; Chu, Gary
Journal of Organic Chemistry, 1982 , vol. 47, # 12 p. 2308 - 2312
反应条件
in water; acetonitrile
T=25°C; pH 7.0; Rate constant;
参考文献
Bunting, John W.; Chew, Vivian S. F.; Chu, Gary
Journal of Organic Chemistry, 1982 , vol. 47, # 12 p. 2308 - 2312
