2-甲基-1,2,3,4-四氢异喹啉合成路线 （共 65 条）
反应条件
1.1: 80 percent / acetone / 20 °C
2.1: 4.50 g / methanol / 0.33 h / 0 °C
3.1: Li; naphthalene / tetrahydrofuran / 2 h / -30 °C
3.2: 95 percent Spectr. / water / tetrahydrofuran / 0.5 h / -30 °C
View Scheme
参考文献
Azzena, Ugo; Pisano, Luisa; Pittalis, Mario
Heterocycles, 2004 , vol. 63, # 2 p. 401 - 409
反应条件
1: NaBH4 / methanol / 1 h / Ambient temperature
2: 97 percent / Ac2O / 1 h / 70 °C
3: 93 percent / aq. NaIO4 / methanol / 20 h / Ambient temperature
4: 1.) TFAA, 2.) BF3*Et2O / 1.) benzene, RT, 0.5 h, 2.) benzene, RT, 2 h
5: 71 percent / NaBH4, NiCl2*6H2O / methanol; tetrahydrofuran / 0.5 h / Ambient temperature
6: 91 percent / LiAlH4 / tetrahydrofuran / 2 h / Heating
View Scheme
参考文献
Shinohara, Tatsumi; Toda, Jun; Sano, Takehiro
Chemical and Pharmaceutical Bulletin, 1997 , vol. 45, # 5 p. 813 - 819
反应条件
1: 97 percent / Ac2O / 1 h / 70 °C
2: 93 percent / aq. NaIO4 / methanol / 20 h / Ambient temperature
3: 1.) TFAA, 2.) BF3*Et2O / 1.) benzene, RT, 0.5 h, 2.) benzene, RT, 2 h
4: 71 percent / NaBH4, NiCl2*6H2O / methanol; tetrahydrofuran / 0.5 h / Ambient temperature
5: 91 percent / LiAlH4 / tetrahydrofuran / 2 h / Heating
View Scheme
参考文献
Shinohara, Tatsumi; Toda, Jun; Sano, Takehiro
Chemical and Pharmaceutical Bulletin, 1997 , vol. 45, # 5 p. 813 - 819
反应条件
1: AcOH / ethanol / 20 h / Heating
2: NaBH4 / methanol / 1 h / Ambient temperature
3: 97 percent / Ac2O / 1 h / 70 °C
4: 93 percent / aq. NaIO4 / methanol / 20 h / Ambient temperature
5: 1.) TFAA, 2.) BF3*Et2O / 1.) benzene, RT, 0.5 h, 2.) benzene, RT, 2 h
6: 71 percent / NaBH4, NiCl2*6H2O / methanol; tetrahydrofuran / 0.5 h / Ambient temperature
7: 91 percent / LiAlH4 / tetrahydrofuran / 2 h / Heating
View Scheme
参考文献
Shinohara, Tatsumi; Toda, Jun; Sano, Takehiro
Chemical and Pharmaceutical Bulletin, 1997 , vol. 45, # 5 p. 813 - 819
反应条件
1: 71 percent / NaBH4, NiCl2*6H2O / methanol; tetrahydrofuran / 0.5 h / Ambient temperature
2: 91 percent / LiAlH4 / tetrahydrofuran / 2 h / Heating
View Scheme
参考文献
Shinohara, Tatsumi; Toda, Jun; Sano, Takehiro
Chemical and Pharmaceutical Bulletin, 1997 , vol. 45, # 5 p. 813 - 819
反应条件
1: 1.) TFAA, 2.) BF3*Et2O / 1.) benzene, RT, 0.5 h, 2.) benzene, RT, 2 h
2: 71 percent / NaBH4, NiCl2*6H2O / methanol; tetrahydrofuran / 0.5 h / Ambient temperature
3: 91 percent / LiAlH4 / tetrahydrofuran / 2 h / Heating
View Scheme
参考文献
Shinohara, Tatsumi; Toda, Jun; Sano, Takehiro
Chemical and Pharmaceutical Bulletin, 1997 , vol. 45, # 5 p. 813 - 819
反应条件
1: 93 percent / aq. NaIO4 / methanol / 20 h / Ambient temperature
2: 1.) TFAA, 2.) BF3*Et2O / 1.) benzene, RT, 0.5 h, 2.) benzene, RT, 2 h
3: 71 percent / NaBH4, NiCl2*6H2O / methanol; tetrahydrofuran / 0.5 h / Ambient temperature
4: 91 percent / LiAlH4 / tetrahydrofuran / 2 h / Heating
View Scheme
参考文献
Shinohara, Tatsumi; Toda, Jun; Sano, Takehiro
Chemical and Pharmaceutical Bulletin, 1997 , vol. 45, # 5 p. 813 - 819
反应条件
1: 92 percent / ethanol / 0.5 h / 60 °C
2: 87 percent / AlCl3 / CHCl3 / 4 h / 25 °C
3: 70 percent / NaBH4 / methanol / 7 h / 25 °C
View Scheme
参考文献
Locher, Cornelia; Peerzada, Naseem
Journal of the Chemical Society - Perkin Transactions 1, 1999 , # 2 p. 179 - 184
反应条件
1: 87 percent / AlCl3 / CHCl3 / 4 h / 25 °C
2: 70 percent / NaBH4 / methanol / 7 h / 25 °C
View Scheme
参考文献
Locher, Cornelia; Peerzada, Naseem
Journal of the Chemical Society - Perkin Transactions 1, 1999 , # 2 p. 179 - 184
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
Inert atmosphereReflux;
参考文献
Allen, Julia M.; Lambert, Tristan H.
Journal of the American Chemical Society, 2011 , vol. 133, # 5 p. 1260 - 1262
