2-甲基-1,2,3,4-四氢异喹啉合成路线 （共 65 条）
反应条件
in acetonitrile Heating;
参考文献
Graulich; Mercier; Scuvee-Moreau; Seutin; Liegeois
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 4 p. 1201 - 1209
反应条件
formic acid; triethylamine; [{(η5-C5Me5)RhCl}2(μ-Cl)2] in dichloromethane
T=40°C; 24 h;
参考文献
PANACEA BIOTEC LIMITED
Patent: WO2009/118765 A2, 2009 ;
Location in patent: Page/Page column 32-33 ;
WO 2009/118765 A2
反应条件
formic acid; water
T=80°C; 24 h;
参考文献
Ebden, Mark R.; Simpkins, Nigel S.; Fox, David N.A.
Tetrahedron, 1998 , vol. 54, # 42 p. 12923 - 12952
反应条件
1: 1,2,3,4-Tetrahydro-isoquinoline; JandaJel-REM in N,N-dimethyl-formamide
T=20°C; Solid phase reaction; Michael addition; 24 h;
2: methyl iodide in N,N-dimethyl-formamide
T=20°C; Solid phase reaction; methylation; 24 h;
3: With NCPS-NEt2 in dichloromethane
T=20°C; Solid phase reaction; elimination; 24 h; Further stages.;
参考文献
Toy, Patrick H.; Reger, Thomas S.; Janda, Kim D.
Organic Letters, 2000 , vol. 2, # 15 p. 2205 - 2207
反应条件
sodium tetrahydroborate in methanol
T=25°C; 7 h;
参考文献
Locher
Synthetic Communications, 2001 , vol. 31, # 19 p. 2895 - 2911
反应条件
hydrogen in hexane
T=160°C; 24 h;
参考文献
Cui, Xinjiang; Dai, Xingchao; Zhang, Yan; Deng, Youquan; Shi, Feng
Chemical Science, 2014 , vol. 5, # 2 p. 649 - 655
反应条件
ammonia; sodium in tetrahydrofuran
T=-78°C; 0.5 h;
参考文献
Tomioka; Koga; Yamada
Chemical and Pharmaceutical Bulletin, 1977 , vol. 25, # 10 p. 2689 - 2691
反应条件
sodium ditelluride in ethanol
Heating;
参考文献
Barton, Derek H. R.; Fekih, Abdelwaheb; Lusinchi, Xavier
Tetrahedron Letters, 1985 , vol. 26, # 50 p. 6197 - 6200
反应条件
tellurium; sodium tetrahydroborate in ethanol
2 h; Heating;
参考文献
Barton, Derek H.R.; Fekih, Abdelwaheb; Lusinchi, Xavier
Tetrahedron Letters, 1985 , vol. 26, # 38 p. 4603 - 4606
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
2 h; Heating;
参考文献
Shinohara, Tatsumi; Toda, Jun; Sano, Takehiro
Chemical and Pharmaceutical Bulletin, 1997 , vol. 45, # 5 p. 813 - 819
