反应条件
1.1: phosphorus tribromide / diethyl ether / 1 h / -20 - 0 °C / Inert atmosphere
2.1: potassium carbonate / acetone / 6 h / 65 °C / Inert atmosphere
3.1: potassium hydroxide; water / methanol / 2 h / 25 - 80 °C
3.2: 0 °C
4.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / -20 °C / Inert atmosphere
4.2: 16 h / -20 - 25 °C / Inert atmosphere
5.1: lithium aluminium tetrahydride / diethyl ether / 1.5 h / -78 - 0 °C / Inert atmosphere
5.2: 2 h
View Scheme
参考文献
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; SNYDER, Scott, Alan; TREITLER, Daniel, S.; BRUCKS, Alexandria, P.; GOLLNER, Andreas; CHIRIAC, Maria, I.; WRIGHT, Nathan, E.; PFLUEGER, Jason, J.; BREAZZANO, Steven, P.
Patent: WO2012/37069 A2, 2012 ;
