2-溴-2,2-二氟-1-苯乙酮合成路线 （共 6 条）
反应条件
bromine in dichloromethane T=-78°C; 0.5 h;
参考文献
Prakash, G.K. Surya; Hu, Jinbo; Alauddin, Mian M.; Conti, Peter S.; Olah, George A.
Journal of Fluorine Chemistry, 2003 , vol. 121, # 2 p. 239 - 243
反应条件
in diethyl ether T=-78°C; Grignard reaction; 3 h;
参考文献
Nihei, Takashi; Iwai, Noritaka; Matsuda, Tomoko; Kitazume, Tomoya
Journal of Organic Chemistry, 2005 , vol. 70, # 15 p. 5912 - 5915
参考文献
Cohn,H.; Bergmann,E.D.
Israel Journal of Chemistry, 1964 , vol. 2, p. 355 - 361
反应条件
sodium hydroxide; sodium tetrahydroborate in methanol
T=-10°C;
参考文献
Norris,R.D.; Binsch,G.
Journal of the American Chemical Society, 1973 , vol. 95, p. 182 - 190
反应条件
1: NaBH4, aq. NaOH / methanol / -10 °C
2: SOCl2, py / 2 h / 60 °C
3: KOtBu / dimethylsulfoxide / 4 h / 50 °C
View Scheme
参考文献
Norris,R.D.; Binsch,G.
Journal of the American Chemical Society, 1973 , vol. 95, p. 182 - 190
反应条件
1: 85 percent / NaH / tetrahydrofuran / 3 h / 0 - 20 °C
2: 96 percent Spectr. / zinc / dimethylformamide / 4 h / 20 °C
3: 80 percent / hydrogen / Pd/C / methanol / 3 h / 3675.29 Torr
View Scheme
参考文献
Nihei, Takashi; Iwai, Noritaka; Matsuda, Tomoko; Kitazume, Tomoya
Journal of Organic Chemistry, 2005 , vol. 70, # 15 p. 5912 - 5915
