2-氨基-4-氯-6-三氟甲基嘧啶合成路线 （共 8 条）
反应条件
triethylamine; trichlorophosphate in acetonitrile 8 h; Reflux;
参考文献
Zhao, Yan-Fang; Liu, Zi-Jian; Zhai, Xin; Ge, Dan-Dan; Huang, Qiang; Gong, Ping
Chinese Chemical Letters, 2013 , vol. 24, # 5 p. 386 - 388
反应条件
ammonia in diethyl ether -5 to 0 deg C then -15 deg C, overnight;
参考文献
Journal of Heterocyclic Chemistry, , vol. 20, # 1 p. 219 - 223
反应条件
1: 70 percent / NH3 / diethyl ether / 1) 5-10 deg C then -15 deg C overnight 2: 83 percent / POCl3 / diethylaniline / 3 h / Heating 3: 20 percent / NH3 / diethyl ether / -5 to 0 deg C then -15 deg C, overnight View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 20, # 1 p. 219 - 223
反应条件
1: 83 percent / POCl3 / diethylaniline / 3 h / Heating 2: 20 percent / NH3 / diethyl ether / -5 to 0 deg C then -15 deg C, overnight View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 20, # 1 p. 219 - 223
反应条件
1: 87 percent / NaOH / H2O / 1) RT, 3 h; 2) reflux, 5 min 2: 79 percent / 10 percent HCl / 8 h / Heating 3: 1) POCl3; 2) PCl5 / 1) reflux, overnight; 2) reflux, overnight 4: 20 percent / NH3 / diethyl ether / -5 to 0 deg C then -15 deg C, overnight View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 20, # 1 p. 219 - 223
反应条件
1: 1) POCl3; 2) PCl5 / 1) reflux, overnight; 2) reflux, overnight 2: 20 percent / NH3 / diethyl ether / -5 to 0 deg C then -15 deg C, overnight View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 20, # 1 p. 219 - 223
反应条件
1: 79 percent / 10 percent HCl / 8 h / Heating 2: 1) POCl3; 2) PCl5 / 1) reflux, overnight; 2) reflux, overnight 3: 20 percent / NH3 / diethyl ether / -5 to 0 deg C then -15 deg C, overnight View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 20, # 1 p. 219 - 223
反应条件
T=20 - 35°C; Substitution;
参考文献
Hamprecht, Gerhard; Mayer, Horst; Westphalen, Karl-Otto; Walter, Helmut
Pesticide Science, 1999 , vol. 55, # 5 p. 566 - 570
