N,N-二甲基氨基甲酸3-(二甲基氨基)苯酯合成路线 （共 9 条）
反应条件
1: 3-dimethylamino-phenol With potassium hydroxide in toluene T=90°C; 1 h; Reflux; 2: p-nitrophenyl dimethylcarbamate in toluene 3 h; Reflux; Product distribution / selectivity;
参考文献
NEON LABORATORIES LTD.; DALVI, Mahesh Bhagoji; KENNY, Rajesh Shashikant; TARADE, Pradeep Kisan; CHINCHKAR, Dattatray Krishna
Patent: WO2012/131699 A1, 2012 ;
Location in patent: Page/Page column 14 ;
参考文献
Barbarini, Jose E.; Rittner, Roberto; Hoeehr, Nelci F.; Suwinski, Jerzy
Bioorganic Chemistry, 1997 , vol. 25, # 1 p. 37 - 41
参考文献
Bobranskii; Eker
Zhurnal Prikladnoi Khimii (Sankt-Peterburg, Russian Federation), 1941 , vol. 14, p. 524,526
Chem.Abstr., 1942 , p. 3159
参考文献
Hoffmann-La Roche
Patent: DE535835 , 1928 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 17, p. 2567
反应条件
water in various solvent(s) T=70 - 95°C; Activation energies in 6 buffer systems with varying pH, influence of buffer concentration, ionic force, oxygen, and pilocarpine hydrochloride on the rates of hydrolysis and demethylation; KineticsThermodynamic dataProduct distribution;
参考文献
Porst; Kny
Pharmazie, 1985 , vol. 40, # 5 p. 325 - 328
反应条件
1) THF, benzene, 0 deg C, 24 h; 2) THF, 12 h, room temperature; Multistep reaction;
参考文献
Ward Jr.; Freeman; Sowell; Kosh
Journal of Pharmaceutical Sciences, 1981 , vol. 70, # 4 p. 433 - 435
反应条件
Yield given. Multistep reaction;
参考文献
Porst; Kny
Pharmazie, 1985 , vol. 40, # 5 p. 325 - 328
反应条件
in acetone T=20°C; four neck round bottom flask;
参考文献
NEON LABORATORIES LTD.; DALVI, Mahesh Bhagoji; KENNY, Rajesh Shashikant; TARADE, Pradeep Kisan; CHINCHKAR, Dattatray Krishna
Patent: WO2012/131699 A1, 2012 ;
Location in patent: Page/Page column 15 ;
