1,2,3,4-四氢-8-甲氧基-4-氧代-2-萘羧酸合成路线 （共 10 条）
反应条件
aluminium trichloride in nitrobenzene 0.0833333 h;
参考文献
Langlois; Gaudy
Synthetic Communications, 1992 , vol. 22, # 12 p. 1723 - 1734
反应条件
1: 47 percent / Na / ethanol / 2 h / Heating 2: 87.6 percent / H2 / 10percent Pd/C / acetic acid 3: 88 percent / acetic anhydride / 2 h / Heating 4: 54 percent / AlCl3 / nitrobenzene / 0.08 h View Scheme
参考文献
Zhang, Yong-Kang; Plattner, Jacob J.; Freund, Yvonne R.; Easom, Eric E.; Zhou, Yasheen; Ye, Long; Zhou, Huchen; Waterson, David; Gamo, Francisco-Javier; Sanz, Laura M.; Ge, Min; Li, Zhiya; Li, Lingchao; Wang, Hailong; Cui, Han
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 3 p. 1299 - 1307
反应条件
1: 88 percent / acetic anhydride / 2 h / Heating 2: 54 percent / AlCl3 / nitrobenzene / 0.08 h View Scheme
参考文献
Zhang, Yong-Kang; Plattner, Jacob J.; Freund, Yvonne R.; Easom, Eric E.; Zhou, Yasheen; Ye, Long; Zhou, Huchen; Waterson, David; Gamo, Francisco-Javier; Sanz, Laura M.; Ge, Min; Li, Zhiya; Li, Lingchao; Wang, Hailong; Cui, Han
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 3 p. 1299 - 1307
反应条件
1: 86 percent / thionyl chloride, pyridine / toluene / Ambient temperature 2: 1.) Na, 3.) 2N NaOH 3: 88 percent / acetic anhydride / 2 h / Heating 4: 54 percent / AlCl3 / nitrobenzene / 0.08 h View Scheme
参考文献
Langlois; Gaudy
Synthetic Communications, 1992 , vol. 22, # 12 p. 1723 - 1734
反应条件
1: 1.) Na, 3.) 2N NaOH 2: 88 percent / acetic anhydride / 2 h / Heating 3: 54 percent / AlCl3 / nitrobenzene / 0.08 h View Scheme
参考文献
Langlois; Gaudy
Synthetic Communications, 1992 , vol. 22, # 12 p. 1723 - 1734
反应条件
1: hydrogenchloride; palladium 10 on activated carbon; hydrogen / tetrahydrofuran / 5 h / 20 °C 2: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 0 °C 3: AlCl3, aluminium chloride / chloroform / 0.5 h / 0 °C View Scheme
参考文献
Zhang, Yong-Kang; Plattner, Jacob J.; Freund, Yvonne R.; Easom, Eric E.; Zhou, Yasheen; Ye, Long; Zhou, Huchen; Waterson, David; Gamo, Francisco-Javier; Sanz, Laura M.; Ge, Min; Li, Zhiya; Li, Lingchao; Wang, Hailong; Cui, Han
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 3 p. 1299 - 1307
反应条件
hydrogen; palladium on activated charcoal in acetic acid T=70 - 80°C; P=760 Torr;
参考文献
Langlois; Gaudy
Synthetic Communications, 1992 , vol. 22, # 12 p. 1723 - 1734
反应条件
1: 96 percent / H2 / 10percent Pd/C / acetic acid / 70 - 80 °C / 760 Torr
2: 75 percent / diphenylphosphoryl azide, Et3N / 18 h / Heating
3: 74 percent / 4N HCl / ethyl acetate / 3 h
View Scheme
参考文献
Langlois; Gaudy
Synthetic Communications, 1992 , vol. 22, # 12 p. 1723 - 1734
反应条件
1: sodium tetrahydroborate; sodium hydroxide / water / 72 h / 20 °C
2: triethylsilane; trifluoroacetic acid / 16 h / 20 °C
3: AlCl3, aluminium chloride / toluene / 2 h / Reflux; Inert atmosphere
View Scheme
参考文献
Zhang, Yong-Kang; Plattner, Jacob J.; Freund, Yvonne R.; Easom, Eric E.; Zhou, Yasheen; Ye, Long; Zhou, Huchen; Waterson, David; Gamo, Francisco-Javier; Sanz, Laura M.; Ge, Min; Li, Zhiya; Li, Lingchao; Wang, Hailong; Cui, Han
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 3 p. 1299 - 1307
反应条件
1: 96 percent / H2 / 10percent Pd/C / acetic acid / 70 - 80 °C / 760 Torr
2: 75 percent / diphenylphosphoryl azide, Et3N / 18 h / Heating
3: 74 percent / 4N HCl / ethyl acetate / 3 h
4: 66 percent / K2CO3 / acetonitrile / 96 h / Ambient temperature
View Scheme
参考文献
Langlois; Gaudy
Synthetic Communications, 1992 , vol. 22, # 12 p. 1723 - 1734
