2-氨基-5-甲基吡啶合成路线 （共 125 条）
反应条件
in acetone T=25 - 30°C; 18 h; Heating / reflux;
参考文献
RANBAXY LABORATORIES LIMITED
Patent: WO2005/10002 A1, 2005 ;
Location in patent: Page/Page column 11 ;
反应条件
hydrogen bromide; bromine in dichloromethane; toluene; acetonitrile
参考文献
Sauter, Markus; Wohlleben, Wolfgang
Patent: US2002/183522 A1, 2002 ;
反应条件
1: methanol / 0.33 h / 30 °C 2: water; potassium hydroxide / ethanol / 30 °C 3: phosphorus pentachloride / dichloromethane / |Reflux 4: dichloromethane / 0.5 h / 0 °C View Scheme
参考文献
Nair, Divya K.; Mobin, Shaikh M.; Namboothiri, Irishi N.N.
Organic Letters, 2012 , vol. 14, # 17 p. 4580 - 4583
反应条件
in acetonitrile 2 h; Reflux;
参考文献
Patil, Sachin S.; Patil, Sachin V.; Bobade, Vivek D.
Organic Preparations and Procedures International, 2011 , vol. 43, # 2 p. 260 - 264
反应条件
1: With sulfuric acid; nitric acid T=0 - 5°C; 2 h; 2: With water; sodium nitrite 4 h; Cooling with ice;
参考文献
Beijing Yiling Bioengineering Co., Ltd.
Patent: EP2366691 A1, 2011 ;
Location in patent: Page/Page column 8-9 ;
反应条件
1: 93 percent / 1.) aq. 48percent HBr, bromine; 2.) aq. sodium nitrite / 1.) -20 deg C, 90 min; 2.) 15 deg C, 1 h 45 min 2: 50 percent / potassium permanganate / aliquat-336 / H2O / 4.5 h / Heating View Scheme
参考文献
Bradlow; Vanderwerf
Journal of Organic Chemistry, 1949 , vol. 14, p. 509,513
反应条件
1: With sulfuric acid T=-10 - 20°C; 1 h; 2: With nitric acid in water T=55 - 60°C; 0.5 h; 3: With sodium hydroxide in water T=0°C; pH=9;
参考文献
CHEMOCENTRYX, INC.
Patent: WO2006/76644 A2, 2006 ;
Location in patent: Page/Page column 204 ;
WO 2006/076644 A2
参考文献
State of Oregon, acting by and through The Oregon State Board of Higher Education, acting for and on behalf of The Oregon Health Sciences University and The University of Oregon, Eugene Oregon; The Regents of the University of California; ACEA Pharmaceuticals, Inc.
Patent: US5620978 A1, 1997 ;
US 5620978 A
反应条件
1: bromine; aqueous sodium nitrite solution; aqueous hydrobromic acid 2: aqueous KMnO4 3: oxalyl chloride; benzene / Behandeln des Reaktionsgemisches mit wss. NH3 View Scheme
参考文献
Bradlow; Vanderwerf
Journal of Organic Chemistry, 1949 , vol. 14, p. 509,513
反应条件
in ethanol 6 h; Heating;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2008/84223 A2, 2008 ;
Location in patent: Page/Page column 423-424 ;
WO 2008/084223 A2
