[(1S,2R)-2-羟基-3-[(2-甲基丙基)氨基]-1-(苯基甲基)丙基]-1,1,-二甲基乙酯合成路线 （共 41 条）
反应条件
in isopropyl alcohol T=20°C;
参考文献
TIBOTEC BVBA
Patent: US2010/305073 A1, 2010 ;
Location in patent: Page/Page column 21-22 ;
反应条件
3S-(N-t-butoxycarbonyl)amino-2R-hydroxy-4-phenylbut-1-yl toluenesulfonate in isopropyl alcohol; toluene T=80 - 85°C; 1.5 h;
参考文献
G. D. Searle and Co.
Patent: US6388132 B1, 2002 ;
Location in patent: Page column 44 ;
反应条件
hydrogen; nickel in tetrahydrofuran P=760 Torr; Ambient temperature;
参考文献
Shibata, Norio; Katoh, Tadashi; Terashima, Shiro
Tetrahedron Letters, 1997 , vol. 38, # 4 p. 619 - 620
反应条件
hydrogen; platinum(IV) oxide in methanol P=7600 Torr; 2 h; Ambient temperature;
参考文献
Yuasa, Yoko; Yuasa, Yoshifumi; Tsuruta, Haruki
Synthetic Communications, 1998 , vol. 28, # 3 p. 395 - 401
反应条件
sodium carbonate in water T=60 - 65°C; 3 h;
参考文献
MYLAN LABORATORIES LTD; VELLANKI, Siva Rama Prasad; SAHU, Arabinda; PHADHURI, Naveen Kumar; KILARU, Ravindrababu
Patent: WO2013/114382 A1, 2013 ;
Location in patent: Page/Page column 7 ;
反应条件
sodium hydrogencarbonate in dichloromethane 5 h; Reflux;
参考文献
WO2011/48604 A2, ;
Page/Page column 18 ;
反应条件
in isopropyl alcohol T=80°C; 6 h;
参考文献
WO2011/61590 A1, ;
Page/Page column 39 ;
反应条件
sodium hydrogencarbonate in dichloromethane 5 h; Reflux;
参考文献
US2012/251826 A1, ;
Page/Page column 9-10 ;
反应条件
1: CH2Cl2 / 3 h / 23 °C 2: 356 mg / H2 / Pd(OH)2 / ethyl acetate; methanol / 12 h 3: 61 percent / PPh3, DEAD / CHCl3 / 72 h / Heating 4: propan-2-ol / 3.5 h / 68 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 63, # 18 p. 6146 - 6152
反应条件
1: KOH / ethanol; H2O / 17 h / Heating 2: CH2Cl2 / 3 h / 23 °C 3: 356 mg / H2 / Pd(OH)2 / ethyl acetate; methanol / 12 h 4: 61 percent / PPh3, DEAD / CHCl3 / 72 h / Heating 5: propan-2-ol / 3.5 h / 68 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 63, # 18 p. 6146 - 6152
