2,6-二氯-3-硝基吡啶合成路线 （共 74 条）
反应条件
1: 67.8 percent / H2O; ethanol / 4 h / 5 - 10 °C
2: 37percent HCl, zinc powder / acetic acid / 0.5 h / 8 - 10 °C
View Scheme
参考文献
MERCK SHARP and DOHME CORP.; ARRINGTON, Kenneth, L.; DUDKIN, Vadim; LAYTON, Mark, E.; PERO, Joseph, E.; REIF, Alexander, J.
Patent: WO2011/156245 A2, 2011 ;
反应条件
1: 67.8 percent / H2O; ethanol / 4 h / 5 - 10 °C
2: 37percent HCl, zinc powder / acetic acid / 0.5 h / 8 - 10 °C
3: 53 percent / CHCl3 / 5 h / Heating
View Scheme
参考文献
MERCK SHARP and DOHME CORP.; LAYTON, Mark, E.; PERO, Joseph, E.; RODZINAK, Kevin, J.; ROSSI, Michael, A.
Patent: WO2011/34741 A1, 2011 ;
WO 2011/034741 A1
反应条件
1: ammonium hydroxide / 5 h / 50 °C
2: ethanol / 16 h / -15 - 20 °C
3: hydrogenchloride; tin(ll) chloride / 5 h / 50 °C
4: methanol / 20 °C
View Scheme
参考文献
VITAS PHARMA RESEARCH PVT LTD; ALAPATI, Chandrasekhar; BANERJEE, Ankita; RANGARAJAN, Radha; KUMAR, Rajinder
Patent: WO2014/57415 A2, 2014 ;
反应条件
sodium carbonate in N,N-dimethyl-formamide
T=0°C; 2 h;
参考文献
YUHAN CORPORATION
Patent: WO2007/1139 A1, 2007 ;
Location in patent: Page/Page column 41 ;
反应条件
1: ammonia
2: triethylamine / dioxane
View Scheme
参考文献
Seydel; Schaper; Coats; Cordes
Journal of Medicinal Chemistry, 1994 , vol. 37, # 19 p. 3016 - 3022
反应条件
1: triethylamine; HCl / CHCl3 / 2 h / -5 - 0 °C
2: 36.4 percent / 13percent ammonia / ethanol / 16 h / 80 °C / autoclave
View Scheme
参考文献
Matsumoto; Miyamoto; Minamida; et al.
Journal of Heterocyclic Chemistry, 1984 , vol. 21, # 3 p. 673 - 679
反应条件
1: NMP / 180 °C
2: Fe, HCl / methanol
3: dimethylsulfoxide
View Scheme
参考文献
Colbry; Elslager; Werbel
Journal of Heterocyclic Chemistry, 1984 , vol. 21, # 5 p. 1521 - 1525
反应条件
1: 86 percent / Na2CO3 / ethanol / 8 h / 20 °C
2: 91 percent / methanol / 3 h / 20 °C
View Scheme
参考文献
Oguchi; Wada; Honma; Tanaka; Kaneko; Sakakibara; Ohsumi; Serizawa; Fujiwara; Horikoshi; Fujita
Journal of Medicinal Chemistry, 2000 , vol. 43, # 16 p. 3052 - 3066
反应条件
1: 58 percent / various solvent(s) / 0.25 h / 178 - 182 °C
2: 34 percent / conc.HCl, iron powder / methanol / 0.5 h / Heating
3: 57 percent / various solvent(s) / 0.17 h / 165 - 190 °C
4: 83 percent / various solvent(s) / 1 h / 195 °C
5: 72 percent / Bromine complex of 1,4-diazabicyclo<2.2.2>octane / aq. acetic acid / 19 h / Ambient temperature
View Scheme
参考文献
Colbry; Elslager; Werbel
Journal of Heterocyclic Chemistry, 1984 , vol. 21, # 5 p. 1521 - 1525
反应条件
1: 58 percent / various solvent(s) / 0.25 h / 178 - 182 °C
2: 34 percent / conc.HCl, iron powder / methanol / 0.5 h / Heating
3: 57 percent / various solvent(s) / 0.17 h / 165 - 190 °C
4: 50 percent / various solvent(s) / 1 h / 195 °C
5: 59 percent / Bromine complex of 1,4-diazabicyclo<2.2.2>octane / aq. acetic acid / 19 h / Ambient temperature
View Scheme
参考文献
Colbry; Elslager; Werbel
Journal of Heterocyclic Chemistry, 1984 , vol. 21, # 5 p. 1521 - 1525
