2,6-二氯-3-硝基吡啶合成路线 （共 74 条）
反应条件
1.1: 1-methyl-pyrrolidin-2-one / 0.67 h / 20 - 180 °C 2.1: ammonium hydroxide; water / 0.33 h / 20 °C 2.2: 3 h / 20 °C View Scheme
参考文献
CHEMIZON, A DIVISION OF OPTOMAGIC CO., LTD.
Patent: US2012/238587 A1, 2012 ;
US 20120238587 A1
反应条件
1: 94.8 percent / SnCl2*2H2O; aq. HCl; acetic acid / 3 h / 20 °C 2: 80.7 percent / pyridine / dioxane; cyclohexane / 16 h / 20 °C View Scheme
参考文献
Khunnawutmanotham, Nisachon; Chimnoi, Nitirat; Saparpakorn, Patchareenart; Pungpo, Pornpan; Louisirirotchanakul, Suda; Hannongbua, Supa; Techasakul, Supanna
Molecules, 2007 , vol. 12, # 2 p. 218 - 230
反应条件
caesium carbonate; tetrakis(triphenylphosphine) palladium(0) in 1,4-dioxane; water T=100°C; 0.166667 h; Microwave irradiation;
参考文献
Smithkline Beecham Corporation
Patent: US2008/242685 A1, 2008 ;
Location in patent: Page/Page column 16 ;
反应条件
potassium phosphate; dichloro(cycloocta-1,5-diene)palladium(II); 1-Mes2B-2-Ph2P-(C6H4) in toluene T=100°C; Suzuki-Miyaura Coupling; 5 h; Schlenk techniqueGloveboxInert atmosphere; Reagent/catalystTime; regioselective reaction;
参考文献
Malacea, Raluca; Chahdoura, Faouzi; Devillard, Marc; Saffon, Nathalie; Gomez, Montserrat; Bourissou, Didier
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 11-12 p. 2274 - 2284
参考文献
Chiron Corporation
Patent: US6417185 B1, 2002 ;
US 6417185 B1
反应条件
ammonia in ethanol T=0°C; 3 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2009/27732 A1, 2009 ;
Location in patent: Page/Page column 69-70 ;
WO 2009/027732 A1
参考文献
UNIVERSITY OF SASKATCHEWAN
Patent: WO2007/45096 A1, 2007 ;
Location in patent: Page/Page column 39; 75 ;
反应条件
1: methanol With sodium hydride in toluene Inert atmosphere; 2: 2,6-dichloro-3-nitro-pyridine in toluene T=0 - 20°C; 16.5 h; Inert atmosphere; regioselective reaction;
参考文献
Yap, Jeremy L.; Hom, Kellie; Fletcher, Steven
Tetrahedron Letters, 2011 , vol. 52, # 32 p. 4172 - 4176
反应条件
1: ammonium hydroxide / 5 h / 50 °C 2: ethanol / 16 h / -15 - 20 °C 3: hydrogenchloride; tin(ll) chloride / 5 h / 50 °C View Scheme
参考文献
VITAS PHARMA RESEARCH PVT LTD; ALAPATI, Chandrasekhar; BANERJEE, Ankita; RANGARAJAN, Radha; KUMAR, Rajinder
Patent: WO2014/57415 A2, 2014 ;
反应条件
potassium fluoride; dimethylsulfone in toluene T=150°C; 1 h;
参考文献
Radl, Stanislav; Hradil, Pavel
Collection of Czechoslovak Chemical Communications, 1991 , vol. 56, # 11.1 p. 2420 - 2429
