2,6-二氯-3-硝基吡啶合成路线 （共 74 条）
反应条件
sulfuric acid; nitric acid in water T=20 - 105°C; 5 h;
参考文献
JUBILANT ORGANOSYS LIMITED
Patent: US2006/80790 A1, 2006 ;
Location in patent: Page/Page column 2 ;
反应条件
hydrogenchloride; triethylamine in chloroform T=-5 - 0°C; 2 h;
参考文献
Journal of Heterocyclic Chemistry, , vol. 21, # 3 p. 673 - 679
反应条件
triethylamine in dichloromethane T=0 - 20°C;
参考文献
WO2010/60955 A1, ;
Page/Page column 19-20 ;
WO 2010/060955 A1
反应条件
triethylamine in dichloromethane T=0 - 20°C;
参考文献
European Journal of Pharmacology, , vol. 709, # 1-3 p. 52 - 63
反应条件
1: 81 percent / dimethylsulfone, KF / toluene / 1 h / 150 °C 2: iron, acetic acid / ethanol / 4 h / Heating View Scheme
参考文献
Radl, Stanislav; Hradil, Pavel
Collection of Czechoslovak Chemical Communications, 1991 , vol. 56, # 11.1 p. 2420 - 2429
反应条件
1: 75 percent / NH3 / ethanol 2: 92 percent / acetic acid, conc. H2SO4 / 2 h / Heating 3: aluminum amalgam, water / ethanol / 4 h / 40 °C 4: 52 percent / 2 h / 100 °C 5: 85percent polyphosphoric acid / 0.17 h / 80 °C View Scheme
参考文献
Radl, Stanislav; Hradil, Pavel
Collection of Czechoslovak Chemical Communications, 1991 , vol. 56, # 11.1 p. 2420 - 2429
反应条件
1: ammonia 2: triethylamine / dioxane View Scheme
参考文献
ARCH PHARMALABS LIMITED; JAGTAP VIKRAM SARJERAO; CHACHE RAVINDRA BABURAO; PATIL DAYAGHAN GANGADHAR; RANBHAN KAMLESH JAYANTILAL
Patent: WO2013/80215 A1, 2013 ;
反应条件
sodium carbonate in ethanol T=20°C; Amination; 8 h;
参考文献
Oguchi; Wada; Honma; Tanaka; Kaneko; Sakakibara; Ohsumi; Serizawa; Fujiwara; Horikoshi; Fujita
Journal of Medicinal Chemistry, 2000 , vol. 43, # 16 p. 3052 - 3066
反应条件
sodium chloride; sodium carbonate; methylamine in ethanol
参考文献
Sankyo Company, Limited
Patent: US5624935 A1, 1997 ;
反应条件
in ethanol; water T=5 - 10°C; 4 h;
参考文献
Bianchi; Butti; Rossi; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 6 p. 501 - 506
