N-(苄氧羰基)-L-丙氨酰-L-丙氨酸合成路线 （共 33 条）
反应条件
triethylamine in tetrahydrofuran
1.5 h; Ambient temperature;
参考文献
Nagao, Yoshimitsu; Miyasaka, Tadayo; Seno, Kaoru; Fujita, Eiichi; Shibata, Daisuke; Doi, Etsushiro
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , p. 2439 - 2446
反应条件
sodium hydroxide in water
24 h; Ambient temperature;
参考文献
Martynov, V. F.; Leont'eva, L. I.; Sorochinskaya, E. I.; Smirnov, A. O.
J. Gen. Chem. USSR (Engl. Transl.), 1984 , vol. 54, # 2 p. 430 - 436,384 - 388
反应条件
1: 6.23 g / industrial papain / 6 h / 50 °C / pH 4,5 (1 N Na2CO3, cysteamine*HCl, buffer citrate)
2: 5.4 g / 2 N NaOH / methanol
View Scheme
参考文献
Moriniere, Jean-Luc; Danree, Bernard; Guy, Alain
European Journal of Medicinal Chemistry, 1987 , vol. 22, p. 347 - 358
反应条件
sodium hydroxide; acetone
参考文献
Stein; Moore; Bergmann
Journal of Biological Chemistry, 1944 , vol. 154, p. 198
反应条件
subtilisin 72*silochrom in N,N-dimethyl-formamide; acetonitrile
T=20°C; Acylation; hydrolysis; 8 h;
参考文献
Voyushina, Tatiana L.; Potetinova, Joanna V.; Milgotina, Ekaterina I.; Stepanov, Valentin M.
Bioorganic and Medicinal Chemistry, 1999 , vol. 7, # 12 p. 2953 - 2959
反应条件
1: 74 percent / N,N'-dicyclohexylcarbodiimide, triethylamine / CH2Cl2 / 24 h / Ambient temperature
2: 70 percent / 1 N NaOH / methanol / below 5 deg C
View Scheme
参考文献
Iida; Yoshimatsu; Sanekata; Fujita
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 11 p. 2997 - 3003
反应条件
sodium hydroxide in 1,4-dioxane
参考文献
Wuensch; Jaeger; Schoensteiner-Altmann
Hoppe-Seyler's Zeitschrift fuer physiologische Chemie, 1971 , vol. 352, # 11 p. 1568 - 1579
反应条件
1: 92 percent / 0.5 h / Ambient temperature
2: 2.) DMF, NMM / 2.) DMF, 30 min., r.t.
3: 88 percent / potassium carbonate / H2O; dimethylformamide / 0.5 h / Ambient temperature
View Scheme
参考文献
Amblard, Muriel; Rodriguez, Marc; Martinez, Jean
Tetrahedron, 1988 , vol. 44, # 16 p. 5101 - 5108
反应条件
1: 2.) DMF, NMM / 2.) DMF, 30 min., r.t.
2: 88 percent / potassium carbonate / H2O; dimethylformamide / 0.5 h / Ambient temperature
View Scheme
参考文献
Amblard, Muriel; Rodriguez, Marc; Martinez, Jean
Tetrahedron, 1988 , vol. 44, # 16 p. 5101 - 5108
反应条件
1: 1.) N-hydroxysuccinimide, dicyclohexylcarbodiimide / 1.) 1,2-dimethoxyethane, 3 h, 0 degC; 2.) 1 h, room temp.
2: 78 percent / 1,8-diazabicyclo<5,4,0>-undec-7-en / benzene / 3 h / Heating
3: 92 percent / 0.5 h / Ambient temperature
4: 2.) DMF, NMM / 2.) DMF, 30 min., r.t.
5: 88 percent / potassium carbonate / H2O; dimethylformamide / 0.5 h / Ambient temperature
View Scheme
参考文献
Amblard, Muriel; Rodriguez, Marc; Martinez, Jean
Tetrahedron, 1988 , vol. 44, # 16 p. 5101 - 5108
