6-氯-N4-(苯基甲基)-4,5-嘧啶二胺合成路线 （共 4 条）
反应条件
triethylamine in ethanol T=50°C;
参考文献
Bristol-Myers Squibb Pharma Company
Patent: US6362180 B1, 2002 ;
Location in patent: Example 2 ;
US 6362180 B1
反应条件
tin(ll) chloride in ethanol 1 h; Heating;
参考文献
Baraldi, Pier Giovanni; Broceta, Asier Unciti; Infantas, Maria Jose Pineda De Las; Mochun, Juan Jose Diaz; Espinosa, Antonio; Romagnoli, Romeo
Tetrahedron, 2002 , vol. 58, # 38 p. 7607 - 7611
反应条件
1: sodium hydrogen carbonate / tetrahydrofuran / 1 h / 55 °C 2: 65 percent / SnCl2*2H2O / ethanol / 1 h / Heating View Scheme
参考文献
Baraldi, Pier Giovanni; Broceta, Asier Unciti; Infantas, Maria Jose Pineda De Las; Mochun, Juan Jose Diaz; Espinosa, Antonio; Romagnoli, Romeo
Tetrahedron, 2002 , vol. 58, # 38 p. 7607 - 7611
反应条件
1: With hydrogenchloride in N,N-dimethyl-formamide 72 h; 2: With triethylamine in N,N-dimethyl-formamide
参考文献
Millennium Pharmaceuticals, Inc.
Patent: US2008/51404 A1, 2008 ;
Location in patent: Page/Page column 120 ;
