六氢-2H-吡啶并[1,2-a]吡嗪-1(6H)-酮合成路线 （共 6 条）
参考文献
G. D. Searle and Co.
Patent: US5461047 A1, 1995 ;
反应条件
hydrazine hydrate in methanol
参考文献
Hoeglund, Iisa P. J.; Silver, Satu; Engstroem, Mia T.; Salo, Harri; Tauber, Andrei; Kyyroenen, Hanna-Kaisa; Saarenketo, Pauli; Hoffren, Anna-Marja; Kokko, Kurt; Pohjanoksa, Katariina; Sallinen, Jukka; Savola, Juha-Matti; Wurster, Siegfried; Kallatsa, Oili A.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 21 p. 6351 - 6363
反应条件
1.1: triflic anhydride / CH2Cl2 / 0.17 h / 0 °C 1.2: 98 percent / 2,6-lutidine; TEA / CH2Cl2 / 20 °C 2.1: hydrazine hydrate / methanol View Scheme
参考文献
Hoeglund, Iisa P. J.; Silver, Satu; Engstroem, Mia T.; Salo, Harri; Tauber, Andrei; Kyyroenen, Hanna-Kaisa; Saarenketo, Pauli; Hoffren, Anna-Marja; Kokko, Kurt; Pohjanoksa, Katariina; Sallinen, Jukka; Savola, Juha-Matti; Wurster, Siegfried; Kallatsa, Oili A.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 21 p. 6351 - 6363
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=20°C; 4 h;
参考文献
Hoeglund, Iisa P. J.; Silver, Satu; Engstroem, Mia T.; Salo, Harri; Tauber, Andrei; Kyyroenen, Hanna-Kaisa; Saarenketo, Pauli; Hoffren, Anna-Marja; Kokko, Kurt; Pohjanoksa, Katariina; Sallinen, Jukka; Savola, Juha-Matti; Wurster, Siegfried; Kallatsa, Oili A.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 21 p. 6351 - 6363
反应条件
sodium hydride
1) benzene, 30 min, reflux, 2) 20h reflux; Yield given. Multistep reaction;
参考文献
Shukla, U. K.; Khanna, J. M.; Sharma, Satyavan; Anand, Nitya; Chatterjee, R. K.; Sen, A. B.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1983 , vol. 22, # 7 p. 664 - 668
反应条件
1: 30percent H2O2 / 24 h / Ambient temperature
2: 25percent aq. NaOH / H2O
View Scheme
参考文献
Thiel, Jacek
Bulletin de l'Academie Polonaise des Sciences, Serie des Sciences Chimiques, 1981 , vol. 29, # 9-10 p. 423 - 430
