potassium carbonate; tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran; water T=70°C; 24 h;

palladium in ethanol; ethyl acetate; Petroleum ether

sodium carbonate in ethylene glycol dimethyl ether; water 5 h; Reflux;

1: 2-bromo-pyridine With isopropylmagnesium chloride in tetrahydrofuran T=30°C; 3.5 h; 2: With zinc(II) chloride in tetrahydrofuran T=20°C; 1.66667 h; 3: (3-iodophenyl)-(7-methoxymethyl-[1,4]-dioxano[2,3-g]quinazolin-4-yl)-amine With tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran 24 h; Reflux;

tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran T=20°C; 24 h; Inert atmosphere;

1: 2-hydroxy-pyridine With potassium carbonate; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate in 1,4-dioxane T=100°C; 3 h; Inert atmosphere; 2: 3-aminobenzeneboronic acid With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in 1,4-dioxane; water T=100°C; Suzuki-Miyaura coupling; Inert atmosphere;