2-氯-6-甲氧基异烟酸合成路线 （共 14 条）
反应条件
sodium methylate 48 h; Heating;
参考文献
Adamczyk, Maciej; Akireddy, Srinivasa Rao; Reddy, Rajarathnam E.
Organic Letters, 2000 , vol. 2, # 22 p. 3421 - 3423
反应条件
in methanol 24 h; Heating / reflux;
参考文献
BIOVITRUM AB
Patent: WO2004/63156 A1, 2004 ;
Location in patent: Page 35 ;
WO 2004/063156 A1
参考文献
DOV PHARMACEUTICAL, INC.
Patent: WO2005/84439 A1, 2005 ;
Location in patent: Page/Page column 41 ;
WO 2005/084439 A1
反应条件
1: With sodium hydroxide 0.5 h; Heating / reflux; 2: With hydrogenchloride in water pH=4 - 6;
参考文献
US2008/132477 A1, ;
Page/Page column 25 ;
反应条件
1: 71 percent / Me4N(1+)*Cl(1-); POCl3 / 29 h / 140 - 150 °C 2: 96 percent / NaOMe / 48 h / Heating View Scheme
参考文献
Tetrahedron, , vol. 58, # 34 p. 6951 - 6963
反应条件
potassium carbonate in N,N-dimethyl-formamide
参考文献
AstraZeneca AB; NPS PHARMACEUTICALS, INC.
Patent: US2007/259923 A1, 2007 ;
Location in patent: Page/Page column 11 ;
US 20070259923 A1
反应条件
sulfuric acid T=65°C; 20 h;
参考文献
Actelion Pharmaceuticals Ltd.
Patent: US2010/63108 A1, 2010 ;
Location in patent: Page/Page column 19 ;
US 20100063108 A1
反应条件
sulfuric acid in methanol 24 h; Reflux;
参考文献
ACTELION PHARMACEUTICALS LTD; BOLLI, Martin; LESCOP, Cyrille; MATHYS, Boris; MORRISON, Keith; MUELLER, Claus; NAYLER, Oliver; STEINER, Beat
Patent: WO2012/98505 A1, 2012 ;
Location in patent: Page/Page column 27 ;
WO 2012/098505 A1
反应条件
1: sulfuric acid / 18 h / 70 °C 2: Pd(dppf) / toluene; 1,4-dioxane / 18 h / 75 °C / Inert atmosphere View Scheme
参考文献
Bolli, Martin; Lescop, Gyrille; Mathys, Boris; Mueller, Claus; Nayler, Oliver; Steiner, Beat
Patent: US2011/46170 A1, 2011 ;
Title/Abstract Full Text Show Details
Bolli, Martin; Lescop, Cyrille; Mathys, Boris; Mueller, Claus; Nayler, Oliver; Steiner, Beat; Velker, Jorg
Patent: US2011/212998 A1, 2011 ;
US 20110212998 A1
反应条件
hydrogen; triethylamine; palladium 10 on activated carbon in methanol T=20°C; P=155.149 Torr;
参考文献
ALMIRALL, S.A.; GRIMA POVEDA, Pedro Manuel; AGUILAR IZQUIERDO, Nuria; MIR CEPEDA, Marta; LOPEZ MARTINEZ, Manuel
Patent: WO2010/43377 A1, 2010 ;
Location in patent: Page/Page column 64 ;
WO 2010/043377 A1
