1: thiourea With 1-methyl-pyrrolidin-2-one; resin bound 4-(benzyloxy)benzyl chloride T=75°C; Alkylation; 16 h; solid phase reaction; 2: (Z)-2-benzylidene-3-oxobutanoic acid ethyl ester With 1-methyl-pyrrolidin-2-one; caesium carbonate T=90°C; Cycloaddition; 16 h; solid phase reaction; 3: With trifluoroacetic acid; ethanethiol in dichloromethane T=20°C; Cleavage; 16 h;

in methanol 16 h; Heating;

1: thiourea With 1-methyl-pyrrolidin-2-one; resin bound 4-(benzyloxy)benzyl chloride T=75°C; Alkylation; 16 h; solid phase reaction; 2: (Z)-2-benzylidene-3-oxobutanoic acid ethyl ester With 1-methyl-pyrrolidin-2-one; caesium carbonate T=90°C; Cycloaddition; 16 h; solid phase reaction; 3: With acetic acid in 1,4-dioxane; ethanol Cleavage; 16 h; Heating;

1: thiourea With 1-methyl-pyrrolidin-2-one; resin bound 4-(benzyloxy)benzyl chloride T=75°C; Alkylation; 16 h; solid phase reaction; 2: (Z)-2-benzylidene-3-oxobutanoic acid ethyl ester With 1-methyl-pyrrolidin-2-one; caesium carbonate T=90°C; Cycloaddition; 16 h; solid phase reaction; 3: With acetic acid in 1,4-dioxane; ethanol Cleavage; 16 h; Heating;

in methanol 16 h; Heating;

in methanol 16 h; Heating;

piperidine in ethanol Ambient temperature;

aluminium trichloride T=0°C; 0.33 h;

piperidine in ethanol Michael addition; 0.133333 h; microwave irradiation;