3-羟基-n-甲基苯甲酰胺合成路线 （共 5 条）
反应条件
in methanol T=155°C; 12 h;
参考文献
MEMORY PHARMACEUTICALS CORP.
Patent: WO2006/71988 A1, 2006 ;
Location in patent: Page/Page column 118 ;
反应条件
1: meta-hydroxy benzoic acid With thionyl chloride in 1,4-dioxane 4 h; Heating / reflux; 2: methylamine in tetrahydrofuran
参考文献
AMGEN INC
Patent: WO2004/85425 A1, 2004 ;
Location in patent: Page 140 ;
WO 2004/085425 A1
反应条件
O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine in acetonitrile T=80°C; 24 h;
参考文献
Tasler, Stefan; Baumgartner, Roland; Ammendola, Astrid; Schachtner, Josef; Wieber, Tanja; Blisse, Marcus; Rath, Sandra; Zaja, Mirko; Klahn, Philipp; Quotschalla, Udo; Ney, Peter
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 20 p. 6108 - 6115
反应条件
1: SOCl2 View Scheme
参考文献
Tilly,G.
Chimica Therapeutica, 1967 , vol. 2, p. 57 - 65
参考文献
Tilly,G.
Chimica Therapeutica, 1967 , vol. 2, p. 57 - 65
