3-氟-4-硝基苯甲酸叔丁酯合成路线 （共 5 条）
反应条件
4-(N,N-dimethlyamino)pyridine; dicyclohexyl-carbodiimide in dichloromethane 24 h;
参考文献
Howes, Peter D.; Cleasby, Anne; Evans, Derek N.; Feilden, Helen; Smith, Paul W.; Sollis, Steven L.; Taylor, Neil; Wonacott, Alan J.
European Journal of Medicinal Chemistry, 1999 , vol. 34, # 3 p. 225 - 234
反应条件
1: 62 percent / SOCl2 / toluene / 3 h / Heating 2: 1.) BuLi / 1.) hexane, 20 deg C, 20 min, 2.) hexane, THF, 22 h View Scheme
参考文献
Springer; Niculescu-Duvaz; Pedley
Journal of Medicinal Chemistry, 1994 , vol. 37, # 15 p. 2361 - 2370
反应条件
1: 59 percent / Na2Cr2O7*2H2O, H2SO4 / H2O / 1 h / 90 °C 2: 79 percent / DMAP, DCC / CH2Cl2 / 24 h View Scheme
参考文献
Howes, Peter D.; Cleasby, Anne; Evans, Derek N.; Feilden, Helen; Smith, Paul W.; Sollis, Steven L.; Taylor, Neil; Wonacott, Alan J.
European Journal of Medicinal Chemistry, 1999 , vol. 34, # 3 p. 225 - 234
反应条件
n-butyllithium 1.) hexane, 20 deg C, 20 min, 2.) hexane, THF, 22 h; Yield given. Multistep reaction;
参考文献
Springer; Niculescu-Duvaz; Pedley
Journal of Medicinal Chemistry, 1994 , vol. 37, # 15 p. 2361 - 2370
反应条件
ammonium formate; palladium on activated charcoal in ethanol
参考文献
Springer; Niculescu-Duvaz; Pedley
Journal of Medicinal Chemistry, 1994 , vol. 37, # 15 p. 2361 - 2370
