N-苄基-对甲苯磺酸胺合成路线 （共 161 条）
反应条件
2: 23 percent / KH / hexamethylphosphoric acid triamide / 72 h / Ambient temperature View Scheme
参考文献
Townsend, Craig A.; Theis, Alan B.
Journal of Organic Chemistry, 1980 , vol. 45, # 9 p. 1697 - 1699
反应条件
1: With n-butyllithium in tetrahydrofuran T=0°C; 2: With naphthalene; lithium in tetrahydrofuran T=-78 - 20°C;
参考文献
Martinez-Asencio, Ana; Ramon, Diego J.; Yus, Miguel
Tetrahedron, 2011 , vol. 67, # 17 p. 3140 - 3149
反应条件
1: (i) NaOMe, ,(ii) O-(2,4-dinitro-phenyl)-hydroxylamine View Scheme
参考文献
Sheradsky,T. et al.
Tetrahedron, 1972 , vol. 28, p. 3833 - 3843
反应条件
1: 90 percent / n-BuLi / tetrahydrofuran; hexane / 2 h / 20 °C 2: 96 percent / PPh3 / tetrahydrofuran / 7 h / 60 °C 3: 80 percent / n-BuLi / tetrahydrofuran; hexane / 2 h / -78 - -30 °C View Scheme
参考文献
Bruckner
Synlett, 2000 , # 10 p. 1402 - 1404
反应条件
1: N-benzyl-4-methylbenzenesulfonamide With n-butyllithium in toluene T=0°C; Metallation; 2: ethynyl(phenyl)iodonium triflate in toluene Alkylation; N-ethynylation;
参考文献
Witulski; Gossmann
Synlett, 2000 , # 12 p. 1793 - 1797
反应条件
1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C 2.1: sodium hydroxide / methanol / 1 h / Reflux 2.2: 20 °C / pH 2 View Scheme
参考文献
Ramunno, Anna; Cosconati, Sandro; Sartini, Stefania; Maglio, Vita; Angiuoli, Sara; La Pietra, Valeria; Di Maro, Salvatore; Giustiniano, Mariateresa; La Motta, Concettina; Da Settimo, Federico; Marinelli, Luciana; Novellino, Ettore
European Journal of Medicinal Chemistry, 2012 , vol. 51, p. 216 - 226
参考文献
Clemo; Perkin
Journal of the Chemical Society, 1925 , vol. 127, p. 2303
反应条件
1: 1.) n-BuLi / 1.) THF, hexane, -78 deg C -> 0 deg C, 30 min, 2.) THF, hexane, -78 deg C -> rt, overnight 2: 1.) Li, naphthalene, 2.) H2O / 1.) THF, -78 deg C, 2 h View Scheme
参考文献
Alonso, Emma; Ramon, Diego J.; Yus, Miguel
Tetrahedron, 1997 , vol. 53, # 42 p. 14355 - 14368
反应条件
1: aqueous alcoholic alkaline solution 2: concentrated hydrochloric acid / 180 °C View Scheme
参考文献
Holmes; Ingold
Journal of the Chemical Society, 1925 , vol. 127, p. 1810
反应条件
2: 54 percent / KH / hexamethylphosphoric acid triamide / 72 h / Ambient temperature View Scheme
参考文献
Townsend, Craig A.; Theis, Alan B.
Journal of Organic Chemistry, 1980 , vol. 45, # 9 p. 1697 - 1699
