aluminium trichloride Acylation;

1: 78 percent / tetrahydrofuran; diethyl ether / 3 h / -30 - 20 °C 2: 87 percent / NaH / tetrahydrofuran / 24 h / Heating View Scheme

1: 80 percent / 4-dimethylaminopyridine / pyridine / 1 h / 0 - 25 °C 2: 73 percent / lithium 2,2,6,6-tetramethylpiperidide / tetrahydrofuran / 30 h / -20 °C 3: sodium carbonate, silver tetrafluoroborate / 8 h / 275 °C / high vacuum View Scheme

1: sodium hydroxide / water / 0 - 20 °C / |Inert atmosphere 2: diethyl ether / -40 - 20 °C / |Inert atmosphere View Scheme

1: triethylamine / tetrahydrofuran / 5 h / 5 - 20 °C / |Inert atmosphere 2: potassium tert-butylate / tetrahydrofuran / 2.5 h / 5 - 20 °C / |Inert atmosphere 3: phosphorus pentachloride / chloroform / |Reflux 4: 1 h / |Reflux 5: water; Na2S*9H2O / ethanol / 4 h / 50 °C 6: triethylamine / tetrahydrofuran / 2 h / 5 - 50 °C / |Inert atmosphere 7: potassium tert-butylate / tetrahydrofuran / 8.5 h / 5 - 50 °C / |Inert atmosphere View Scheme

1.1: dichloromethane / 24 h / 20 °C / |Inert atmosphere 2.1: lithium diisopropyl amide / hexane; tetrahydrofuran / 2 h / -78 °C / |Inert atmosphere 2.2: 2.5 h / -78 °C / |Inert atmosphere 3.1: hydrogenchloride / 1,4-dioxane; water / 1 h / 20 °C / |Inert atmosphere 3.2: 16 h / 20 °C / |Inert atmosphere 3.3: 6 h / 20 °C / |Inert atmosphere 4.1: lithium aluminium tetrahydride / diethyl ether / 0.75 h / 0 - 20 °C / |Inert atmosphere 5.1: triphenylphosphine; di-isopropyl azodicarboxylate; diphenyl phosphoryl azide / tetrahydrofuran / 12 h / -10 - 20 °C / |Inert atmosphere 6.1: lithium aluminium tetrahydride / diethyl ether / 1 h / 0 - 20 °C / |Inert atmosphere 7.1: triethylamine; 1-propanephosphonic acid cyclic anhydride / ethyl acetate / 6 h / 20 °C / |Inert atmosphere 8.1: boron trifluoride diethyl etherate / dichloromethane / 36 h / 0 - 20 °C / |Inert atmosphere 9.1: (SPY-5-31)-dichloro-(κ2(C,O)-(2-isopropyloxybenzylidene))(1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidene)ruthenium / dichloromethane / 18 h / 40 °C / |Inert atmosphere 10.1: 5 palladium on charcoal; hydrogen / ethanol / 16 h / 20 °C View Scheme

1: 80 percent / pyridine / tetrahydrofuran / 4 h / 0 - 5 °C 2: 625 mg / HCl / dimethylformamide / 16 h / 50 °C 3: 90 percent / dimethylformamide / 3 h / 50 °C 4: 40 percent / trimethylphosphate, POCl3 / 3 h / 0 - 5 °C View Scheme

in tetrahydrofuran

暂无反应条件数据

aluminium chloride in dichloromethane; water