3-溴-1,2-二氨基苯合成路线 （共 14 条）
反应条件
tin(ll) chloride in ethanol 2 h; Reflux;
参考文献
F. HOFFMANN-LA ROCHE AG; ALIAGAS-MARTIN, Ignacio; CRAWFORD, James; LEE, Wendy; MATHIEU, Simon; RUDOLPH, Joachim
Patent: WO2013/26914 A1, 2013 ;
Location in patent: Page/Page column 108 ;
WO 2013/026914 A1
反应条件
1: With sodium tetrahydroborate; CoCl2.6H2O in methanol 3 h; Reflux; 2: With water
参考文献
Wasik, Romualda; Winska, Patrycja; Poznanski, Jaroslaw; Shugar, David
Journal of Physical Chemistry B, 2012 , vol. 116, # 24 p. 7259 - 7268
反应条件
1: hydrogen bromide; bromine / 3 h / Reflux 2: hydrogenchloride; tin(ll) chloride / water / 2 h / 20 °C View Scheme
参考文献
Journal of Physical Chemistry B, , vol. 116, # 24 p. 7259 - 7268
反应条件
hydrogenchloride; tin(ll) chloride
参考文献
Bollettino Scientifico della Facolta di Chimica Industriale di Bologna, , vol. 11, p. 42
反应条件
1.1: thionyl chloride / toluene / 3 h / Reflux 1.2: 19 h / Reflux 2.1: hydrogen bromide; bromine / 3 h / Reflux 3.1: hydrogenchloride; tin(ll) chloride / water / 2 h / 20 °C View Scheme
参考文献
Journal of Physical Chemistry B, , vol. 116, # 24 p. 7259 - 7268
反应条件
1: ethanol / Reflux 2: trichlorophosphate View Scheme
参考文献
Porter, John; Lumb, Simon; Lecomte, Fabien; Reuberson, James; Foley, Anne; Calmiano, Mark; le Riche, Kelly; Edwards, Helen; Delgado, Jean; Franklin, Richard J.; Gascon-Simorte, Jose M.; Maloney, Alison; Meier, Christoph; Batchelor, Mark
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 2 p. 397 - 400
参考文献
Porter, John; Lumb, Simon; Lecomte, Fabien; Reuberson, James; Foley, Anne; Calmiano, Mark; le Riche, Kelly; Edwards, Helen; Delgado, Jean; Franklin, Richard J.; Gascon-Simorte, Jose M.; Maloney, Alison; Meier, Christoph; Batchelor, Mark
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 2 p. 397 - 400
参考文献
F. HOFFMANN-LA ROCHE AG; ALIAGAS-MARTIN, Ignacio; CRAWFORD, James; LEE, Wendy; MATHIEU, Simon; RUDOLPH, Joachim
Patent: WO2013/26914 A1, 2013 ;
Location in patent: Page/Page column 108 ;
WO 2013/026914 A1
反应条件
toluene-4-sulfonic acid in tetrahydrofuran T=60°C; 0.333333 h; Inert atmosphere;
参考文献
AMGEN INC.; ASHTON, Kate; BARTBERGER, Michael D.; BOURBEAU, Matthew Paul; CROGHAN, Michael D.; FOTSCH, Christopher H.; HUNGATE, Randall W.; KONG, Ke; NISHIMURA, Nobuko; NORMAN, Mark H.; PENNINGTON, Lewis D.; REICHELT, Andreas; SIEGMUND, Aaron C.; TADESSE, Seifu; ST. JEAN, David Jr; YANG, Kevin C.; YAO, Guomin
Patent: WO2013/173382 A1, 2013 ;
Location in patent: Page/Page column 199 ;
参考文献
Hollstein, Ulrich; Krisov, Galen E.
Organic Magnetic Resonance, 1980 , vol. 14, # 4 p. 300 - 304
