2-甲基-2-丙基(2-碘-4-甲氧基苯基)氨基甲酸酯合成路线 （共 13 条）
反应条件
1: With tert.-butyl lithium in diethyl ether 2: With 1,2-di-iodoethane in diethyl ether T=-78 - 20°C; Further stages.;
参考文献
Edwankar, Chitra R.; Edwankar, Rahul V.; Namjoshi, Ojas A.; Liao, Xuebin; Cook, James M.
Journal of Organic Chemistry, 2013 , vol. 78, # 13 p. 6471 - 6487
反应条件
in tetrahydrofuran 48 h; Inert atmosphereReflux;
参考文献
Jana, Goutam Kumar; Sinha, Surajit
Tetrahedron, 2012 , vol. 68, # 35 p. 7155 - 7165
反应条件
1: With triethylamine in dichloromethane T=0°C; 2: With tert.-butyl lithium in diethyl ether T=0°C; 3: With 1,2-di-iodoethane T=-78 - 20°C;
参考文献
Edwankar, Chitra R.; Edwankar, Rahul V.; Namjoshi, Ojas A.; Liao, Xuebin; Cook, James M.
Journal of Organic Chemistry, 2013 , vol. 78, # 13 p. 6471 - 6487
反应条件
1: 92 percent / tetrahydrofuran / 18 h / Ambient temperature 2: 1.) t-BuLi, 2.) I2 / 1.) Et2O, pentane, -20 deg C, 3 h, 2.) Et2O, pentane, -100 deg C -> rt, overnight View Scheme
参考文献
Ozawa, Tsukasa; Kanematsu, Makoto; Yokoe, Hiromasa; Yoshida, Masahiro; Shishido, Kozo
Heterocycles, 2012 , vol. 85, # 12 p. 2927 - 2932
反应条件
1: 92 percent / tetrahydrofuran / 18 h / Ambient temperature 2: 1.) t-BuLi, 2.) I2 / 1.) Et2O, pentane, -20 deg C, 3 h, 2.) Et2O, pentane, -100 deg C -> rt, overnight View Scheme
参考文献
Ozawa, Tsukasa; Kanematsu, Makoto; Yokoe, Hiromasa; Yoshida, Masahiro; Shishido, Kozo
Heterocycles, 2012 , vol. 85, # 12 p. 2927 - 2932
反应条件
1.1: p-sulfobenzenediazonium chloride; potassium hydroxide / water / 0.5 h / 20 °C / Inert atmosphere 1.2: 0.33 h / 45 °C / Inert atmosphere 2.1: caesium carbonate / N,N-dimethyl-formamide / 48 h / 20 °C / Inert atmosphere 3.1: tetrahydrofuran / 48 h / Inert atmosphere; Reflux View Scheme
参考文献
Jana, Goutam Kumar; Sinha, Surajit
Tetrahedron, 2012 , vol. 68, # 35 p. 7155 - 7165
反应条件
1: caesium carbonate / N,N-dimethyl-formamide / 48 h / 20 °C / Inert atmosphere 2: tetrahydrofuran / 48 h / Inert atmosphere; Reflux View Scheme
参考文献
Jana, Goutam Kumar; Sinha, Surajit
Tetrahedron, 2012 , vol. 68, # 35 p. 7155 - 7165
反应条件
1: 4-(N,N-dimethlyamino)pyridine / tetrahydrofuran / 6 h / |Reflux 2: methanol; potassium carbonate / 6 h / |Reflux View Scheme
参考文献
Lee, Won-Il; Jung, Jong-Wha; Sim, Jaehoon; An, Hongchan; Suh, Young-Ger
Tetrahedron, 2013 , vol. 69, # 35 p. 7211 - 7219
反应条件
1: caesium carbonate / acetonitrile / 20 °C 2: isopropylmagnesium chloride lithium chloride complex / tetrahydrofuran / 1 h / -78 °C 3: acetyl chloride / ethanol / 1.17 h / 20 - 50 °C View Scheme
参考文献
Kobayashi, Yuichi; Igarashi, Junji; Feng, Chao; Toshifumi; Tojo
Tetrahedron Letters, 2012 , vol. 53, # 29 p. 3742 - 3745
反应条件
1: 80 percent / (i-Pr)2NEt, BnNEt3(1+)*Cl(1-), Pd(OAc)2 / dimethylformamide / 2 h / 75 °C 2: 84 percent / p-TsOH / ethanol / 13 h / Ambient temperature View Scheme
参考文献
Heterocycles, , vol. 41, # 8 p. 1627 - 1630
