2-溴-3-吡啶基三氟甲磺酸酯合成路线 （共 5 条）
反应条件
pyridine T=-10 - 23°C; 1.75 h;
参考文献
McArthur, Silvia Gatti; Goetschi, Erwin; Palmer, Wylie Solang; Wichmann, Juergen; Woltering, Thomas Johannes
Patent: US2006/217387 A1, 2006 ;
Location in patent: Page/Page column 27 ;
US 20060217387 A1
反应条件
1: 38 percent / Et3N / Pd(PPh3)2Cl2, LiCl / dimethylformamide / 2 h / 55 °C 2: 1.) n-BuLi / 1.) Et2O, hexane, -78 deg C, 1 h, 2.) Et2O, hexane, -78 deg C, 30 min; -78 deg C to r.t., 10 min 3: 23 percent / NH2OH*HCl, NaOAc / ethanol / Ambient temperature View Scheme
参考文献
Numata, Atsushi; Kondo, Yoshinori; Sakamoto, Takao
Synthesis, 1999 , # 2 p. 306 - 311
反应条件
1: 38 percent / Et3N / Pd(PPh3)2Cl2, LiCl / dimethylformamide / 2 h / 55 °C 2: 1.) n-BuLi / 1.) Et2O, hexane, -78 deg C, 1 h, 2.) Et2O, hexane, -78 deg C, 30 min; -78 deg C to r.t., 10 min 3: 58 percent / NH3 / ethanol / 2 h / 80 °C View Scheme
参考文献
Numata, Atsushi; Kondo, Yoshinori; Sakamoto, Takao
Synthesis, 1999 , # 2 p. 306 - 311
反应条件
bis-triphenylphosphine-palladium(II) chloride; triethylamine; lithium chloride in N,N-dimethyl-formamide
T=55°C; 14 h;
参考文献
Martin, Ruben; Rivero, Marta Rodriguez; Buchwald, Stephen L.
Angewandte Chemie - International Edition, 2006 , vol. 45, # 42 p. 7079 - 7082
反应条件
1: 72 percent / LiCl; dichlorobis(triphenylphosphine)palladium(II); Et3N / dimethylformamide / 14 h / 55 °C
2: 83 percent / CuI; trans-N,N-dimethyl-1,2-dicyclohexylamine / 12 h / 120 °C
View Scheme
参考文献
Martin, Ruben; Rivero, Marta Rodriguez; Buchwald, Stephen L.
Angewandte Chemie - International Edition, 2006 , vol. 45, # 42 p. 7079 - 7082
