lithium hydroxide in tetrahydrofuran Ambient temperature;
参考文献
Salituro, Francesco G.; Harrison, Boyd L.; Baron, Bruce M.; Nyce, Philip L.; Stewart, Kenneth T.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 10 p. 1791 - 1799
1.1: diphenylether / 4 h / 250 °C 2.1: potassium carbonate / dimethyl sulfoxide / 1 h / 70 °C 2.2: 2 h / 35 °C 3.1: sodium hydroxide / methanol; water / 2 h / Cooling with ice View Scheme
1.1: methanol / 18 h / Reflux 2.1: diphenylether / 4 h / 250 °C 3.1: potassium carbonate / dimethyl sulfoxide / 1 h / 70 °C 3.2: 2 h / 35 °C 4.1: sodium hydroxide / methanol; water / 2 h / Cooling with ice View Scheme
