2-氰基-2-甲基丙酸乙酯合成路线 （共 29 条）
反应条件
1: cyanoacetic acid ethyl ester With sodium hydride in tetrahydrofuran T=20°C; Cooling with ice; 2: methyl iodide in tetrahydrofuran T=20°C; 3 h;
参考文献
BIOGEN IDEC MA INC.; THOMAS, Jermaine; LIU, Xiaogao; LIN, Edward, Yin-Shiang; ZHENG, Guo, Zhu; MA, Bin; CALDWELL, Richard, D.; GUCKIAN, Kevin, M.; KUMARAVEL, Gnanasambandam; TAVERAS, Arthur, G.
Patent: WO2011/17561 A1, 2011 ;
Location in patent: Page/Page column 61 ;
WO 2011/017561 A1
反应条件
acetic acid; dimethyl sulfate in tetrahydrofuran; water
参考文献
Sumika Fine Chemicals Co., Ltd.
Patent: US2003/144533 A1, 2003 ;
反应条件
sodium hydroxide; tetrabutylammomium bromide in dichloromethane T=10 - 40°C;
参考文献
WO2012/21446 A2, ;
Page/Page column 29 ;
反应条件
sodium hydride in N,N-dimethyl-formamide; benzene Ambient temperature;
参考文献
Murakami, Yukito; Hisaeda, Yoshio; Ozaki, Toshiaki; Tashiro, Takako; Ohno, Teruhisa; et al.
Bulletin of the Chemical Society of Japan, 1987 , vol. 60, # 1 p. 311 - 324
反应条件
potassium carbonate in N,N-dimethyl-formamide T=15 - 30°C;
参考文献
WO2010/112482 A1, ;
Page/Page column 28 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide T=10 - 35°C;
参考文献
WO2010/112482 A1, ;
Page/Page column 28 ;
反应条件
1: cyanoacetic acid ethyl ester With sodium hydride in N,N-dimethyl-formamide T=0°C; 0.5 h; 2: methyl iodide in tetrahydrofuran; N,N-dimethyl-formamide T=20°C; 71.75 h; Product distribution / selectivity;
参考文献
EP1717238 A1, ;
Page/Page column 60 ;
反应条件
cobalt complex of 2,10-diethyl-3,9-dipropyl-1,4,8,11-tetraazaundeca-1,3,8,10-tetraene-1,11-diol electrolytic process;
参考文献
Chemistry Letters, , # 5 p. 835 - 838
反应条件
1: 68 percent / NaH / dimethylformamide; benzene / 2 h / Ambient temperature 2: TBAF / <Cob(II)7C1ester>ClO4 / dimethylformamide / 20 h / 20 °C / electrolysis with Pt electrodes, with or without CH3COOH additive, irradiation, various time, and potential View Scheme
参考文献
Bulletin of the Chemical Society of Japan, , vol. 60, # 1 p. 311 - 324
反应条件
meta-chloroperoxybenzoic acid; APClt;C2Lys(C5N(1+))2C14gt;4; tri-n-butyl-tin hydride in dichloromethane; water T=10°C; dark;
参考文献
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), , p. 1237 - 1246
