4-[二(2-羟基乙基)氨基]-苯甲酸乙酯合成路线 （共 5 条）
反应条件
1: With acetic acid in water T=20°C; 24 h; Cooling; 2: With ammonia in water
参考文献
Zheng, Qing-Zhong; Zhang, Fei; Cheng, Kui; Yang, Ying; Chen, Yu; Qian, Yong; Zhang, Hong-Juan; Li, Huan-Qiu; Zhou, Chang-Fang; An, Shu-Qing; Jiao, Qing-Cai; Zhu, Hai-Liang
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 2 p. 880 - 886
反应条件
water; acetic acid; acetone
参考文献
Ross et al.
Journal of the Chemical Society, 1955 , p. 3110,3115
反应条件
1: With thionyl chloride in benzene
3 h; Reflux;
2: With hydrogenchloride; water
3 h; Reflux;
参考文献
Zheng, Qing-Zhong; Zhang, Fei; Cheng, Kui; Yang, Ying; Chen, Yu; Qian, Yong; Zhang, Hong-Juan; Li, Huan-Qiu; Zhou, Chang-Fang; An, Shu-Qing; Jiao, Qing-Cai; Zhu, Hai-Liang
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 2 p. 880 - 886
反应条件
triethylamine in dichloromethane
T=-14 - 20°C; 3.5 h;
参考文献
ABBOTT LABORATORIES
Patent: US2011/237553 A1, 2011 ;
Location in patent: Page/Page column 35 ;
反应条件
chloroform; phosphorus pentachloride
参考文献
Everett; Ross
Journal of the Chemical Society, 1949 , p. 1972,1974
